Role of cyclooxygenase-2 in tumor progression and immune regulation in lung cancer.

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dc.contributor.authorPatel, Swatien_US
dc.contributor.authorChiplunkar, Shubhadaen_US
dc.date.accessioned2007-12-07en_US
dc.date.accessioned2009-05-27T09:46:16Z
dc.date.available2007-12-07en_US
dc.date.available2009-05-27T09:46:16Z
dc.date.issued2007-12-07en_US
dc.description93 references.en_US
dc.description.abstractLung cancer is the leading cause of cancer death all over the world. The low 5-year survival rate (under 15%) has changed minimally in the last 25 years. Amongst different types of lung cancers, non-small cell lung carcinoma (NSCLC) types account 25-40%. To improve the survival of lung cancer patients, new therapeutic strategies are needed. The search for improved therapies has led to the investigation of agents that target novel pathways involved in tumor proliferation, invasion, survival and immune regulation. Cyclooxygenase-2 (COX-2) is one of the novel targets under evaluation for NSCLC therapy and chemoprevention. Although multiple genetic alterations are necessary for lung cancer invasion and metastasis, COX-2 may act as central element in orchestring these processes. COX-2 plays an important role in all aspects of tumor development and growth. It also plays a pivotal role in regulation of cytokines and immune responses in NSCLC patients. In this article, we review the experimental and clinical evidences on the possible link between COX and NSCLC.en_US
dc.description.affiliationChiplunkar Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410 210, India.en_US
dc.identifier.citationPatel S, Chiplunkar S. Role of cyclooxygenase-2 in tumor progression and immune regulation in lung cancer. Indian Journal of Biochemistry & Biophysics. 2007 Dec; 44(6): 419-28en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28509
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshCyclooxygenase 2 --physiologyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshHumansen_US
dc.subject.meshImmune System --physiologyen_US
dc.subject.meshLung Neoplasms --enzymologyen_US
dc.titleRole of cyclooxygenase-2 in tumor progression and immune regulation in lung cancer.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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