Protective effect of Withania somnifera roots extract on hematoserological profiles against lead nitrate-induced toxicity in mice.

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dc.contributor.authorSharma, Veena
dc.contributor.authorSharma, Sadhana
dc.contributor.authorPracheta
dc.date.accessioned2012-12-31T05:08:27Z
dc.date.available2012-12-31T05:08:27Z
dc.date.issued2012-12
dc.description.abstractThe in vivo protective role of hydro-methanolic root extract of Withania somnifera (WS) was evaluated in alleviating lead nitrate (LN)-induced toxicity in male Swiss albino mice by measuring hematoserological profiles. The lead-treated (20 mg/kg body wt, p.o.) albino mice (25-30 g) concurrently received the root extract (200 and 500 mg/kg body wt, p.o.) once daily for the duration of six weeks. Animals exposed to LN showed significant (P<0.001) decline in haemoglobin content, red blood cell count, white blood cell count, packed cell volume and insignificant decrease in mean corpuscular haemoglobin and mean corpuscular haemoglobin content, while mean corpuscular volume and platelet count were increased. A significant elevation (P<0.001) in serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, acid phosphatase and total cholesterol were also observed, when compared with control mice. Thus, the study demonstrated that the concurrent daily administration of root extract of WS protected the adverse effects of LN intoxication in mice.en_US
dc.identifier.citationSharma Veena, Sharma Sadhana, Pracheta. Protective effect of Withania somnifera roots extract on hematoserological profiles against lead nitrate-induced toxicity in mice. Indian Journal of Biochemistry & Biophysics. 2012 Dec; 49(6): 458-462.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144087
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/15238en_US
dc.subjectWithania somniferaen_US
dc.subjectLead nitrateen_US
dc.subjectAlbino miceen_US
dc.subjectBlood profilesen_US
dc.subject.meshAlbinism --veterinary
dc.subject.meshAnimals
dc.subject.meshBlood --pathology
dc.subject.meshBlood Cell Count
dc.subject.meshLead --toxicity
dc.subject.meshMice
dc.subject.meshNitrates --toxicity
dc.subject.meshWithania
dc.titleProtective effect of Withania somnifera roots extract on hematoserological profiles against lead nitrate-induced toxicity in mice.en_US
dc.typeArticleen_US
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