Effects of verapamil and nifedipine on psychomotor performance in human subjects.

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dc.contributor.authorJaguste, V Sen_US
dc.contributor.authorDadkar, V Nen_US
dc.contributor.authorDhar, H Len_US
dc.date.accessioned1991-06-01en_US
dc.date.accessioned2009-05-31T02:03:49Z
dc.date.available1991-06-01en_US
dc.date.available2009-05-31T02:03:49Z
dc.date.issued1991-06-01en_US
dc.description.abstractThe present study was undertaken to evaluate the effects of two structurally dissimilar calcium channel blockers, verapamil (a phenylalkylamine) in a single dose of 40 and 80 mg, and nifedipine (a dihydropyridine) in a single dose of 10 and 15 mg, on psychomotor performance and higher mental functions in human volunteers. Placebo and diazepam (5 mg) were used as negative and positive controls respectively. For evaluating these functions, tests employed were arithmetic ability, visual and auditory reaction time, letter (alphabet) cancellation, rapid fire arithmetic deviation and short term memory for playing cards. Careful record was kept of the heart rate, blood pressure and side effects of the therapy, each time the psychomotor tests were performed. Verapamil, both in 40 and 80 mg dose, was found to impair the performance of subjects to a significant extent in auditory reaction time, letter cancellation and short term memory. These effects were similar to those observed with administration of diazepam. With nifedipine, impairment in performance was observed only in rapid arithmetic deviation test. Thus, calcium channel antagonists, specially verapamil, impaired psychomotor performance of human subjects in our study.en_US
dc.description.affiliationDepartment of Pharmacology, LTM Medical College, Sion, Bombay.en_US
dc.identifier.citationJaguste VS, Dadkar VN, Dhar HL. Effects of verapamil and nifedipine on psychomotor performance in human subjects. Journal of the Association of Physicians of India. 1991 Jun; 39(6): 457-62en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/92716
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshDiazepam --pharmacologyen_US
dc.subject.meshDrug Evaluationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Rate --drug effectsen_US
dc.subject.meshHigher Nervous Activity --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNifedipine --administration & dosageen_US
dc.subject.meshPsychomotor Performance --drug effectsen_US
dc.subject.meshVerapamil --administration & dosageen_US
dc.titleEffects of verapamil and nifedipine on psychomotor performance in human subjects.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
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