A critical evaluation of signs and symptoms in the diagnosis of Addison's diseases.

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dc.contributor.authorZargar, A Hen_US
dc.contributor.authorLaway, B Aen_US
dc.contributor.authorMasoodi, S Ren_US
dc.contributor.authorBashir, M Ien_US
dc.contributor.authorWani, A Ien_US
dc.contributor.authorSalahuddin, Men_US
dc.date.accessioned2001-05-22en_US
dc.date.accessioned2009-05-30T17:47:29Z
dc.date.available2001-05-22en_US
dc.date.available2009-05-30T17:47:29Z
dc.date.issued2001-05-22en_US
dc.description.abstractOBJECTIVES: To determine the usefulness of clinical symptoms and signs in the diagnosis of Addison's disease. METHODOLOGY: A retrospective, hospital based study from analysis of case records of over 12 years period (1988-1999). Individual or groups of signs and symptoms in 66 patients of confirmed Addison's diseases were compared with 76 subjects with normal ACTH stimulation test, when clinical presentations were similar. RESULTS: Age spectrum of the two groups was similar. Signs and symptoms like weakness, weight loss, gastro-intestinal disturbances, skin/mucosal pigmentation and blood pressure were not statistically different between the two groups. Similarly blood glucose, sodium and potassium were not different between the two groups. Combination of three or more symptoms/signs had a high predictive value of diagnosing the disease than any individual or a combination of < 3 signs/symptoms (P=0.033). CONCLUSIONS: Combination of skin and mucosal pigmentation with gut disturbances and weight loss carried high predictive value in diagnosis of Addison's disease, while individual sign and symptom has poor differentiating value.en_US
dc.description.affiliationDepartment of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences Srinagar, Kashmir.en_US
dc.identifier.citationZargar AH, Laway BA, Masoodi SR, Bashir MI, Wani AI, Salahuddin M. A critical evaluation of signs and symptoms in the diagnosis of Addison's diseases. Journal of the Association of Physicians of India. 2001 May; 49(): 523-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/85223
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAddison Disease --blooden_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshWeight Lossen_US
dc.titleA critical evaluation of signs and symptoms in the diagnosis of Addison's diseases.en_US
dc.typeJournal Articleen_US
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