Protein Expression of p53 and CD44 in Patients with Cancer of Buccal Mucosa

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dc.contributor.authorTrivedi, Truptien_US
dc.contributor.authorPrajapati, Sureshen_US
dc.contributor.authorKobawala, Toralen_US
dc.contributor.authorGhosh, Nanditaen_US
dc.contributor.authorPatel, Prabhudasen_US
dc.date.accessioned2020-01-02T06:17:44Z
dc.date.available2020-01-02T06:17:44Z
dc.date.issued2017-01
dc.description.abstractBackground:In India, the incidence of cancer of buccal mucosa is a serious public health issue where a large fraction is related to the poor treatment outcome. Identification of high-risk oral premalignant lesions could constitute as one of the key factors in reducing the morbidity, mortality and cost of treatment associated with oral squamous cell carcimnoma (OSCC).Methods: Total 62 subjects of buccal mucosa lesions were enrolled in this study. Using immunohistochemistry, expression of p53 and CD44 was studied from paraffin embedded tumor tissue blocks. Results: Nuclear p53 expression was significantly higher in premalignant lesions compared to malignant tumors (P=0.037), and also in early stage OSCC patients (P=0.012). On correlating CD44 protein expression with different clinicopathological parameters of OSCC patients, significant inverse correlation of CD44 was observed with lymphnode metastasis (P=0.042) and tumor stage (P=0.042).Conclusion: p53 expression is associated with patients having premalignant lesions & having significant higher risk of progressing to OSCC. Expression of both, p53 and CD44 were found to be early events in oral cancer. Thus, for identifying high risk OSCC patients for better patient management, p53 and CD44 might be useful significant biomarkers; however, further study in more number of patients is needed to identify their precise role in oral carcinogenesis.en_US
dc.identifier.affiliationsSenior Scientific Officer & In-Charge Clinical Carcinogenesis Lab-3, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, Indiaen_US
dc.identifier.affiliationsStudnet, M.Sc. Cancer Biology Clinical Carcinogenesis Lab-3. The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, Indiaen_US
dc.identifier.affiliationsResearch Assistant, Tumor Biology Lab-2 The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, Indiaen_US
dc.identifier.affiliationsSenior Scientific Officer, Tumor Biology Lab-2,The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, Indiaen_US
dc.identifier.affiliationsProfessor & Head, Department Cancer Biology,The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, Indiaen_US
dc.identifier.citationTrivedi Trupti, Prajapati Suresh, Kobawala Toral, Ghosh Nandita, Patel Prabhudas. A Sole t(10;19)(p11.2;p12) in AML-ETO negative AML-M2 paediatric patient: First novel case from India. GCSMC Journal of Medical Sciences journal. 2017 Jan; 6(1): 60-63en_US
dc.identifier.issn2278-7399
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189752
dc.languageenen_US
dc.publisherGCS Medical College, Hospital & Research Centreen_US
dc.relation.issuenumber1en_US
dc.relation.volume6en_US
dc.titleProtein Expression of p53 and CD44 in Patients with Cancer of Buccal Mucosaen_US
dc.typeJournal Articleen_US
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