The effect of ephedrine on the onset time of rocuronium in Thai patients.

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dc.contributor.authorIttichaikulthol, Wichaien_US
dc.contributor.authorSriswasdi, Suriraten_US
dc.contributor.authorNual-on, Supawadeeen_US
dc.contributor.authorHongpuang, Sompawunen_US
dc.contributor.authorSornil, Asneeen_US
dc.date.accessioned2009-05-27T18:47:09Z
dc.date.available2009-05-27T18:47:09Z
dc.date.issued2004-03-01en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThe aim of this study was to determine the effect of ephedrine on the onset time of rocuronium. The study population was 60 ASA physical status 1 and 2 patients, aged 15-60 years scheduled for elective surgery under general anesthesia at Ramathibodi Hospital. The patients were randomly assigned into 2 groups. Group I (ephedrine group), ephedrine 70 microg/kg was given 1 minute before induction and group II (control group), saline was given instead of ephedrine and midazolam 7.5 mg was given orally 30-60 minutes before the induction. Anesthesia was induced with fentanyl 1 microg/kg and sodium thiopentone 3-5 mg/kg. The patient was intubated with 0.9 mg/kg of rocuronium. The intubation time (from rocuronium administration to the time of intubation) was predetermined by the Dixon's up and down method (with 5 seconds as a step size) for each patient and started at 60 seconds for the first patient in each group. The intubation time in the ephedrine group (39.41 +/- 4.64 seconds) was significantly different from the control group (59.17 +/- 9.00 seconds); p-value < 0.01. The hemodynamics were similar in both groups. Conclusion: Intravenous ephedrine shortened the onset time of rocuronium with no significant adverse hemodynamic effects. As an alternative to suxamethonium for rapid intubation, the authors recommend the use of ephedrine 70 microg/kg at one minute before induction followed by 0.9 mg/kg of rocuronium intravenously in healthy patients. The intubation could be achieved at 40 seconds after the administration.en_US
dc.description.affiliationDepartment of Anesthesiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.en_US
dc.identifier.citationIttichaikulthol W, Sriswasdi S, Nual-on S, Hongpuang S, Sornil A. The effect of ephedrine on the onset time of rocuronium in Thai patients. Journal of the Medical Association of Thailand. 2004 Mar; 87(3): 264-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/39845
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAndrostanols --pharmacologyen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshEphedrine --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntubation, Intratrachealen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReaction Time --drug effectsen_US
dc.subject.meshThailanden_US
dc.subject.meshTime Factorsen_US
dc.titleThe effect of ephedrine on the onset time of rocuronium in Thai patients.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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