The predictive value of sFlt-1/PIGF ratio in high risk patients for the development of preeclampsia

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dc.contributor.authorSunil, Ishaen_US
dc.contributor.authorSharma, Mitalien_US
dc.date.accessioned2020-10-16T07:58:51Z
dc.date.available2020-10-16T07:58:51Z
dc.date.issued2019-09
dc.description.abstractBackground: Hypertensive disorders of pregnancy constitute a major cause of maternal morbidity and mortality. Pre-eclampsia/eclampsia ranks second only to haemorrhage as a specific, direct cause of maternal mortality. A number of markers have been under study for the early detection of this disease. The study aims to evaluate the predictive value of sFlt-1/PlGF ratio for preeclampsia.Methods: This study was conducted in the Department of Gynaecology and Obstetrics of ASCOMS hospital, Jammu for a period of 6 months from Jan 2019 to June 2019. 50 antenatal patients attending the outpatient department with risk factors for developing preeclampsia were enrolled in the study. Their sFlT-1/PIGF ratio was determined at gestational age of 20 weeks to 37 weeks and its predictive value was evaluated.Results: In the present study, 8 patients developed preeclampsia subsequently. The mean sFlt-1/PIGF ratio values were significantly higher in the patients who developed preeclampsia (73.5) than who did not develop the disease (26.07). The positive predictive value at 1 week was 41.66% and negative predictive value was 100%. At 4 weeks, positive predictive value was 66.66% and negative predictive value was 100%.Conclusions: The present study suggests sFlt-1/PIGF ratio values are useful marker was a predictor of preeclampsia and values >38 were associated with preeclampsia. It is more useful in ruling out preeclampsia than ruling in the disease.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Acharya Shri Chander College of Medical Sciences, Jammu, J&k, Indiaen_US
dc.identifier.citationSunil Isha, Sharma Mitali. The predictive value of sFlt-1/PIGF ratio in high risk patients for the development of preeclampsia. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2019 Sep; 8(9): 3705-3709en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/207039
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber9en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20193802en_US
dc.subjectPreeclampsiaen_US
dc.subjectPredictive markeren_US
dc.subjectsFlt-1/PIGF ratioen_US
dc.titleThe predictive value of sFlt-1/PIGF ratio in high risk patients for the development of preeclampsiaen_US
dc.typeJournal Articleen_US
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