Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish

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dc.contributor.authorMohesh, Gen_US
dc.contributor.authorPradeep, Pen_US
dc.contributor.authorS, RKen_US
dc.contributor.authorMeerasa, SSen_US
dc.contributor.authorGovindasamy, V.en_US
dc.date.accessioned2023-06-27T06:38:53Z
dc.date.available2023-06-27T06:38:53Z
dc.date.issued2022-10
dc.description.abstractBackground: Herbs used in medicinal practices by the indigenous healers are found to be of great importance in the management of diseases that are yet to have a cure by the available drugs. Practice of using herbs available in the vicinity by the locals as medication for ailments is a universal phenomenon. Dendropthoe falcata, an arboreal parasitic plant used in the indigenous medicine for the management of diabetes, is explored here for its acute hyperglycemic model adult zebrafishes. Aim and Objectives: The aim of the study was to determine the hypoglycemic effect of the methanolic extract of Dendrophthoe falcata leaves in alloxan-induced acute diabetic adult zebrafish. Materials and Methods: Adult zebrafishes were grouped into five groups with six fishes in each group exposing them to alloxan to induce acute hyperglycemia and then treating them with two test doses of 40 mg/dl and 60 mg/dl of the methanolic extract of the plant extract. Another group was treated with metformin with a dosage of 20 micro moles. Body mass index, blood glucose, and histopathological examination pre- and post-treatment for a period of 14 days were studied. Results: The effect of the herbal extract in both the doses was promising when compared with the standard drug metformin; however, the cytoprotective effect was very predominant with the both doses of the extract. Acute hypoglycemic was comparatively good when compared with the standard group treated with metformin. Conclusion: The antidiabetic effect of the arboreal parasitic plant has been established with a need for further exploration of this plant for a potential drug for diabetes mellitus.en_US
dc.identifier.affiliationsDepartment of Physiology, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth, Ammapettai, Chengalpattu, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth, Ammapettai, Chengalpattu, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, College of Medicine, Shaqra University, Riyadh Province, Kingdom of Saudi Arabiaen_US
dc.identifier.affiliationsMBBS Student, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth, Ammapettai, Chengalpattu, Tamil Nadu, India.en_US
dc.identifier.citationMohesh G, Pradeep P, S RK, Meerasa SS, Govindasamy V.. Effect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafish. National Journal of Physiology, Pharmacy and Pharmacology. 2022 Oct; 12(10): 1692-1697en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217757
dc.languageenen_US
dc.publisherMrs Dipika Charan of MedScience (India) Publicationsen_US
dc.relation.issuenumber10en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2022.12.02075202214022022en_US
dc.subjectDiabetes Mellitusen_US
dc.subjectDendropthoe falcataen_US
dc.subjectHypoglycemic Effecten_US
dc.subjectMedicinal Herbsen_US
dc.subjectCytoprotectiveen_US
dc.subjectArboreal Parasite Planten_US
dc.titleEffect of methanolic extract of Dendrophthoe falcata leaves on acute hyperglycemic adult zebrafishen_US
dc.typeJournal Articleen_US
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