Diagnosis of acute humoral rejection using immunofluorescence in renal allograft biopsies- one step towards better understanding!

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dc.contributor.authorVanikar, Aruna Ven_US
dc.contributor.authorTrivedi, Hargovinden_US
dc.contributor.authorPatel, Rashmi Den_US
dc.contributor.authorKanodia, Kamal Ven_US
dc.contributor.authorTrivedi, Varsha Ben_US
dc.contributor.authorShah, Pankaj Ren_US
dc.contributor.authorGupta, Sonia Ben_US
dc.contributor.authorDabhi, Manishen_US
dc.contributor.authorGumber, Manojen_US
dc.contributor.authorGoplani, Kamalen_US
dc.date.accessioned2007-07-22en_US
dc.date.accessioned2009-05-29T12:30:13Z
dc.date.available2007-07-22en_US
dc.date.available2009-05-29T12:30:13Z
dc.date.issued2007-07-22en_US
dc.description.abstractImmunofluorescence (IF) studies are important diagnostic tool in understanding pathogenesis involved in graft injury. Acute humoral rejection (AHR) associated with circulating donor-specific cytotoxic antibodies, is a poor prognosticator for graft survival. It can be diagnosed by staining for C4d antibody using indirect IF technique. C4d staining required to diagnose AHR was made mandatory for reporting renal allograft biopsies in 7th Banff conference. We present 2 years experience of IF studies using C4d polyclonal antibody on 546 renal allograft biopsies belonging to two groups of patients; 464 from group A (tolerance induction protocol) and 82 from group B (controls). We observed C4d focal positivity in 4 (0.9%) biopsies from group A and 4 (4.9%) from group B. We conclude that it is advisable to collect simultaneous core biopsy samples for IF studies and light microscopy to give better definition of allograft injury and thereby support in clinical management.en_US
dc.description.affiliationDepartment of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Smt. G.R. Doshi and Smt. K.M. Mehta Institute of Kidney Diseases and Research Centre, Ahmedabad. vanikararuna@yahoo.comen_US
dc.identifier.citationVanikar AV, Trivedi H, Patel RD, Kanodia KV, Trivedi VB, Shah PR, Gupta SB, Dabhi M, Gumber M, Goplani K. Diagnosis of acute humoral rejection using immunofluorescence in renal allograft biopsies- one step towards better understanding! Indian Journal of Pathology & Microbiology. 2007 Jul; 50(3): 502-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74660
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntibodies, Monoclonal --immunologyen_US
dc.subject.meshBiopsyen_US
dc.subject.meshChilden_US
dc.subject.meshComplement C4b --analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Technique, Indirecten_US
dc.subject.meshGraft Rejection --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Transplantation --immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeptide Fragments --analysisen_US
dc.subject.meshTransplantation, Homologous --immunologyen_US
dc.titleDiagnosis of acute humoral rejection using immunofluorescence in renal allograft biopsies- one step towards better understanding!en_US
dc.typeJournal Articleen_US
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