Recurrence rates after functional surgery versus amputation for nail squamous cell carcinoma not involving the bone: A systematic review

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dc.contributor.authorWong, H-Sen_US
dc.contributor.authorLi, Fen_US
dc.contributor.authorJiang, J-Yen_US
dc.contributor.authorHuang, S-Den_US
dc.contributor.authorJi, Xen_US
dc.contributor.authorZhu, Pen_US
dc.contributor.authorWang, D-G.en_US
dc.date.accessioned2025-06-18T11:42:23Z
dc.date.available2025-06-18T11:42:23Z
dc.date.issued2025-02
dc.description.abstractBackground: Nail unit squamous cell carcinoma (nSCC) is a malignant subungual tumour. Although it has a low risk of metastasis and mortality, the tumour has a significant local recurrence rate. There is insufficient data to determine whether functional surgery is less effective than amputation for nSCC that does not involve the bone. Objectives: We aimed to investigate existing data on the outcomes of functional surgery and amputation for nSCC without bone invasion. Materials and Methods: We carried out an extensive search in PubMed, Embase, Cochrane Library, Web of Science, and Scopus for appropriate English-language academic papers, starting with the creation of individual resources until February 23, 2023. The main outcome was local recurrence. Initially, 2191 studies related to nSCC were selected. Information from every research study was retrieved and subdivided, comprising the year of publication, period, number of patients, age, gender distribution, tumour stage, type of intervention, number of recurrences, and follow-up period. Results: Ten independent studies (319 lesions) were finally selected. Mohs micrographic surgery was the most reported surgical modality, followed by wide surgical excision and amputation. Local recurrence rates between Mohs micrographic surgery, wide surgical excision and amputation treatment were nearly identical. Other surgical methods included limited surgical excision, partial ablation, and limited excision until the clearing of margins, with recurrence rates up to 50%. Conclusions: Given the functional impairment and psychological distress associated with phalanx amputation, functional surgery, including Mohs micrographic surgery and wide surgical excision , should be the preferred therapy for nSCC without bone involvement. Amputation should remain the preferred therapy for nSCC that involves the bone. Partial excision should be avoided. Further studies on whether Mohs micrographic surgery or wide surgical excision is a better option for nSCC not involving the bone are required.en_US
dc.identifier.affiliationsDepartment of Dermatology and Venereology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Chinaen_US
dc.identifier.affiliationsDepartment of Dermatology and Venereology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Chinaen_US
dc.identifier.affiliationsDepartment of Dermatology and Venereology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Chinaen_US
dc.identifier.affiliationsDepartment of Dermatology and Venereology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Chinaen_US
dc.identifier.affiliationsDepartment of Dermatology and Venereology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Chinaen_US
dc.identifier.affiliationsDepartment of Dermatology and Venereology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Chinaen_US
dc.identifier.affiliationsDepartment of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Chinaen_US
dc.identifier.citationWong H-S, Li F, Jiang J-Y, Huang S-D, Ji X, Zhu P, Wang D-G.. Recurrence rates after functional surgery versus amputation for nail squamous cell carcinoma not involving the bone: A systematic review. Indian Journal of Dermatology, Venereology and Leprology. 2025 Feb; 91(1): 31-39en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249400
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists (IADVL), India.en_US
dc.relation.issuenumber1en_US
dc.relation.volume91en_US
dc.source.urihttps://dx.doi.org/10.25259/IJDVL_912_2023en_US
dc.subjectamputationen_US
dc.subjectfunctional surgeryen_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectsystematic reviewen_US
dc.subjectnail diseaseen_US
dc.titleRecurrence rates after functional surgery versus amputation for nail squamous cell carcinoma not involving the bone: A systematic reviewen_US
dc.typeJournal Articleen_US
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