Current applications of proteomics: a key and novel approach

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dc.contributor.authorSharma, Vipin Kumaren_US
dc.contributor.authorKumar, Ravien_US
dc.date.accessioned2020-04-09T07:42:51Z
dc.date.available2020-04-09T07:42:51Z
dc.date.issued2019-11
dc.description.abstractProteomics represented vital applications of technologies in the identification and quantification of high to moderate proteins (cellular signalling networks) found in biological matrix such as tissues, cells and fluids. Proteomics based technical knowledge is applied and verified in several preclinical research settings such as invention of diagnostic markers for specific disease and have shown to be increased in clinical applications. Extensive studies on proteomics resulted in detection of biomarkers that have been highly advanced in using diseases for cancer, lungs, cardiovascular, renal and neuro-regenerative and Parkinson's disease by introducing human origins for biocompatibility such as urine and serum. Advancement in the proteomic methods is conferring candidate right direction for clinical usage. In this review, recent developments and widely used proteomics approaches such as Mass Spectrometry (MS), Microarray chips are elaborately addressed and also focused merits and demerits of commonly used advanced approaches such as Selected Reaction Monitoring (SRM), Parallel Reaction Monitoring (PRM) and Data Independent Acquisition (DIA) and other used proteomics and that roles, in order to aid clinicians, were also discussed in the light of biomedical applications.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Central University of Haryana, Jant Pali, Mahendergarh, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Internal Medicine, Armed Forces Medical College, Pune, Maharashtra, Indiaen_US
dc.identifier.citationSharma Vipin Kumar, Kumar Ravi. Current applications of proteomics: a key and novel approach. International Journal of Advances in Medicine. 2019 Nov; 6(6): 1953-1960en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194436
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20195259en_US
dc.subjectBiomarkersen_US
dc.subjectBiomedical applicationsen_US
dc.subjectMass Spectrometryen_US
dc.subjectMicroarray chipsen_US
dc.subjectParallel reaction monitoringen_US
dc.subjectProtein quantificationen_US
dc.titleCurrent applications of proteomics: a key and novel approachen_US
dc.typeJournal Articleen_US
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