Effect of Zinc Supplementation on Adenosine Deaminase Activity in Leprosy.

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dc.contributor.authorPradhan, T
dc.contributor.authorKumari, S
dc.date.accessioned2015-04-17T03:55:34Z
dc.date.available2015-04-17T03:55:34Z
dc.date.issued2013-10
dc.description.abstractSerum Adenosine Deaminase (ADA) acts as marker of cellular immunity and its activity is found to be altered in various diseases in which there is a cell mediated immune response (CMI) including leprosy. The role of zinc is well established in the development and maintainence of immunocompetence and its supplementation activates the immune response in particular Tlymphocytes and monocytes in several ways. The aim of the study was planned to evaluate the effect of nutritional zinc supplementation on cell mediated immune response by investigating the pre and post intervention serum ADA levels after oral zinc sulphate supplementation in leprosy patients. A total of 49 cases, 30 Tuberculoid Leprosy (TT) and 19 Lepromatous Leprosy (LL) patients, within the age group of 25-60 years were enrolled in the study along with 30 age matched healthy controls. Serum ADA was estimated in all the subjects before and after (2 months and 4 months) oral zinc supplementation. Pre intervention serum ADA level was observed to be significantly increased in both the TT and LL (p<0.001) groups as compared to controls, revealing raised immunological activity in the patients. After oral zinc sulphate supplementation serum ADA re-evaluation was done in 38 cases. A highly significant (p < 0.001 ) rise in ADA level was registered in the post intervention period (4 months supplementation) in TT cases with a moderately significant (p< 0.05) increase in LL cases, indicating the ability of oral zinc therapy to affectively alter the cell mediated immune response in leprosy.en_US
dc.identifier.citationPradhan T, Kumari S. Effect of Zinc Supplementation on Adenosine Deaminase Activity in Leprosy. Indian Medical Gazette. 2013 Oct ; 147 (10): 376-380.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/157553
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ice/t13/i10/icet13i10p376.pdfen_US
dc.subjectadenosine deaminase (ADA)en_US
dc.subjectcell mediated immunity (CMI)en_US
dc.subjectzincen_US
dc.subject.meshAdenosine Deaminase --blood
dc.subject.meshAdenosine Deasminase --metabolism
dc.subject.meshAdult
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunity, Cellular
dc.subject.meshLeprosy --diet therapy
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshZinc --administration & dosage
dc.subject.meshZinc --therapeutic use
dc.subject.meshZinc Sulfate --administration & dosage
dc.subject.meshZinc Sulfate --therapeutic use
dc.titleEffect of Zinc Supplementation on Adenosine Deaminase Activity in Leprosy.en_US
dc.typeArticleen_US
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