Effect of household exposure to environmental tobacco smoke on airflow mechanics in asymptomatic healthy women.

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dc.contributor.authorAggarwal, A Nen_US
dc.contributor.authorGupta, Dheerajen_US
dc.contributor.authorSharma, C Pen_US
dc.contributor.authorJindal, S Ken_US
dc.date.accessioned2004-01-05en_US
dc.date.accessioned2009-05-27T08:39:47Z
dc.date.available2004-01-05en_US
dc.date.available2009-05-27T08:39:47Z
dc.date.issued2004-01-05en_US
dc.description.abstractBACKGROUND & OBJECTIVES: Exposure to environmental tobacco smoke (ETS) can lead to airflow limitation, similar to that seen in smokers. However, the effects have not been conclusively proven. In the present study an attempt was made to characterize the effect of ETS exposure at home on airflow mechanics in asymptomatic healthy women. METHODS: Fifty women volunteers with no apparent health related problem, exposed to household ETS (group I), and 50 age-matched women not exposed (group II) were studied. Vital capacity (VC), forced expiratory flow in first second (FEV1), FEV1/VC ratio, peak expiratory flow (PEF), maximal midexpiratory flow (FEF(25-75%)), airway resistance (R(aw)) and specific airway conductance (sG(aw)) were measured, and compared between the two groups. Conditional logistic and linear regression analysis were done to assess contribution of household ETS exposure to decreased lung function. RESULTS: FEV1 and PEF values were marginally lower among women in group I (mean difference 0.13 l and 0.20 l/sec respectively). FEF(25-75%), R(aw) and sG(aw) were significantly impaired in this group. Ten (20.0%) women in group I and five (10.0%) in group II had abnormal R(aw) (adjusted odds ratio 6.72, 95% confidence limits 1.15-39.42), while eight (16.0%) women in group I and one (2.0%) in group II had abnormal sG(aw) (adjusted odds ratio 21.08, 95% confidence limits 1.30-341.05). Cumulative life time ETS exposure was, not significantly related to a reduction in FEV1, VC, PEF, FEF(25-75%), R(aw) or sG(aw) after adjustments for potential confounders. INTERPRETATION & CONCLUSION: Exposure to household ETS resulted in subtle impairment of airflow mechanics in asymptomatic women, possibly attributed to small airway narrowing. Further investigations are required to study the progression of this impairment with time.en_US
dc.description.affiliationDepartment of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.en_US
dc.identifier.citationAggarwal AN, Gupta D, Sharma CP, Jindal SK. Effect of household exposure to environmental tobacco smoke on airflow mechanics in asymptomatic healthy women. Indian Journal of Medical Research. 2004 Jan; 119(1): 18-23en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/25220
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAirway Resistance --drug effectsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFamily Characteristicsen_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Flow Rates --drug effectsen_US
dc.subject.meshForced Expiratory Volume --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPeak Expiratory Flow Rate --drug effectsen_US
dc.subject.meshRespiration --drug effectsen_US
dc.subject.meshSmokingen_US
dc.subject.meshTobacco --adverse effectsen_US
dc.subject.meshTobacco Smoke Pollutionen_US
dc.titleEffect of household exposure to environmental tobacco smoke on airflow mechanics in asymptomatic healthy women.en_US
dc.typeJournal Articleen_US
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