Prurigo as the early sign of HIV infection: a review

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dc.contributor.authorAryani, NMen_US
dc.contributor.authorSuryana, Ken_US
dc.date.accessioned2025-06-18T11:13:49Z
dc.date.available2025-06-18T11:13:49Z
dc.date.issued2025-06
dc.description.abstractPrurigo is a common dermatological condition in HIV-infected individuals, particularly those with low CD4 counts. This condition can be the first manifestation and as the early sign of HIV-infected individuals. One form of prurigo in HIV-positive patients is prurigo nodularis. It presents with intensely pruritic, hyperkeratotic papules or nodules lesions, significantly impairing quality of life. The pathogenesis of PN involves complex immune dysregulation, including Th2-mediated inflammation and the release of cytokines like IL-31, which contribute to inflammation and pruritus. HIV infection exacerbates these processes, making PN more prevalent and severe in immunocompromised individuals. Early detection of prurigo and appropriate treatment, including rapid antiretroviral therapy, can help reduce the frequency and severity of prurigo in HIV-positive patients. Current treatments include topical steroids, UV therapy and systemic medications, with novel therapies targeting specific cytokines under investigation. Dermatologists are also encouraged to screen for psychiatric comorbidities due to the profound psychosocial impact of PN. This review aims especially for health workers to remind the importance of early detection of dermatological signs of prurigo in patients at risk of HIV, as an important step in improving clinical outcomes and patient quality of life.en_US
dc.identifier.affiliationsDepartment of Internal Medicine, Wangaya General Hospital, Denpasar, Bali, Indonesiaen_US
dc.identifier.affiliationsDepartment of Internal Medicine, Wangaya General Hospital, Denpasar, Bali, Indonesiaen_US
dc.identifier.citationAryani NM, Suryana K. Prurigo as the early sign of HIV infection: a review. International Journal of Advances in Medicine. 2025 Jun; 12(3): 329-332en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/248369
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2349-3933.ijam20251085en_US
dc.subjectAntiretroviral therapyen_US
dc.subjectCytokinesen_US
dc.subjectHIVen_US
dc.subjectInflammation and pruritusen_US
dc.subjectPrurigo nodularisen_US
dc.titlePrurigo as the early sign of HIV infection: a reviewen_US
dc.typeJournal Articleen_US
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