Clinico-laboratory profile of haemolytic uremic syndrome.

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dc.contributor.authorJha, D Ken_US
dc.contributor.authorSingh, Ren_US
dc.contributor.authorRaja, Sen_US
dc.contributor.authorKumari, Nen_US
dc.contributor.authorDas, B Ken_US
dc.date.accessioned2009-05-28T03:58:24Z
dc.date.available2009-05-28T03:58:24Z
dc.date.issued2007-10-08en_US
dc.descriptionKathmandu University Medical Journal.en_US
dc.description.abstractOBJECTIVE: To study the clinical profile, the spectrum of functional abnormalities, prognostic factors and outcome of children with haemolytic uremic syndrome (HUS). MATERIALS AND METHODS: This is a prospective, descriptive, single centre, cohort study, conducted on 42 children during the period of January 2004 to January 2005. RESULTS: The maximum numbers of cases were below 24 months of age with mean age of 26.6 months and male: female ratio of 2.8:1. Most of the cases (79%) occurred in the warmer months (April-September). The common clinical presentations were bloody diarrhoea, pallor, oliguria & anuria, fever, vomiting, abdominal distension and pain, involvement of central nervous system, chest and cardiovascular system and bleeding manifestations. The common haematological abnormalities were leucocytosis, thrombocytopenia, anaemia and features of haemolysis in the peripheral blood. Electrolyte abnormalities observed were in the form of hyponatremia, hypokalemia and hyperkalemia. Arterial blood gas analysis showed metabolic acidosis in 64% cases, where the estimations were done. The mean blood urea and serum creatinine levels were 113.7 mg/dL and 2.5 mg/dL, respectively. Stool examination showed blood in all cases. Urine examination showed microscopic haematuria and significant proteinuria in 74% and 38% cases, respectively. E. coli and Shigella were isolated in stool in three cases each and one case showed mixed growth of E. coli and Salmonella. The mortality rate was 21%. Significantly higher mortality was observed in females, patients presenting with complete anuria, leucocytosis, hyperkalemia and systemic involvement like central nervous system, cardio vascular system and chest. CONCLUSIONS: Female sex, complete anuria, leucocytosis, extra renal involvement and hyperkalemia were associated with poor outcome.en_US
dc.description.affiliationDepartment of Pediatrics and Adolescent Medicine, B P Koirala Institute of Health Sciences, Dharan, Nepal.en_US
dc.identifier.citationJha DK, Singh R, Raja S, Kumari N, Das BK. Clinico-laboratory profile of haemolytic uremic syndrome. Kathmandu University Medical Journal. 2007 Oct-Dec; 5(4): 468-74en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/46202
dc.language.isoengen_US
dc.source.urihttps://www.kumj.com.npen_US
dc.source.urihttps://kumj.com.np/ftp/issue/20/468-474%20CLINICO%20LABORATORY%20PROFILE%20OF%20HEMOLYTIC%20UREMIC%20SYNDROME.pdfen_US
dc.subject.meshAnti-Bacterial Agents --therapeutic useen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHemolytic-Uremic Syndrome --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNepal --epidemiologyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRisk Factorsen_US
dc.titleClinico-laboratory profile of haemolytic uremic syndrome.en_US
dc.typeJournal Articleen_US
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