Apolipoprotein B - An ideal biomarker for atherosclerosis?
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Date
2024-03
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Elsevier
Abstract
This review article describes the pathophysiological mechanisms linking Apolipoprotein B (Apo-B) and athero- sclerosis, summarizes the existing evidence on Apo B as a predictor of atherosclerotic cardiovascular disease and recommendations of (inter)national treatment guidelines regarding Apo B in dyslipidemia management. A single Apo B molecule is present in every particle of very low-density lipoprotein, intermediate density lipoprotein, low density lipoprotein, and lipoprotein(a). This unique single Apo B per particle ratio makes plasma Apo B con- centration a direct measure of the number of circulating atherogenic lipoproteins. This review of global evidence on Apo B as a biomarker for atherosclerosis confirms that Apo B is a single atherogenic lipid marker present in all lipids sub-fractions except HDL-C, and thus, Apo B integrates and extends the information from triglycerides and cholesterol, which could simplify and improve care for atherosclerotic cardiovascular disease.
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Keywords
Apo-lipoprotein B, Atherosclerosis, India, Dyslipidaemia, Biomarker
Citation
Singh Kavita, Prabhakaran Dorairaj . Apolipoprotein B - An ideal biomarker for atherosclerosis?. Indian Heart Journal. 2024 Mar; 76(1): 121-129