Characteristics of Siblings With Celiac Disease Diagnosed by Family Screening

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dc.contributor.authorAkkelle, Bilge Sen_US
dc.contributor.authorVolkan, Burcuen_US
dc.contributor.authorTutar, Enginen_US
dc.contributor.authorErtem, Denizen_US
dc.date.accessioned2023-08-25T06:39:26Z
dc.date.available2023-08-25T06:39:26Z
dc.date.issued2022-11
dc.description.abstractObjective: The aim of this study was to evaluate the features of asymptomatic siblings of index celiac patients who were diagnosed with celiac disease (CD) at the initial screening. Methods: We reviewed hospital records of 210 children with CD. The characteristics of sibling celiacs (n=24) were compared with index celiacs (n=186). Results: At diagnosis, sibling celiacs were older than index celiacs (mean (SD) 10.4 (2.7) vs 8.2 (4.3) years; P=0.02). There were no significant differences between sibling and index celiacs in terms of serum anti-tTG IgA titer (?10xULN, 83.3% vs 85%), and most of the patients had moderate/severe villous atrophy in both groups. The rates of iron deficiency anemia, folic acid deficiency, wasting and stunting were comparable between sibling and index celiac patients. Conclusions: Siblings with CD were older than index children with CD at diagnosis, and their characteristics were similar to symptomatic index children with CD, despite not having any complaints.en_US
dc.identifier.affiliationsMarmara University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Istanbul, Turkey.en_US
dc.identifier.citationAkkelle Bilge S, Volkan Burcu, Tutar Engin, Ertem Deniz. Characteristics of Siblings With Celiac Disease Diagnosed by Family Screening. Indian Pediatrics. 2022 Nov; 59(11): 867-870en_US
dc.identifier.issn0079-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225270
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber11en_US
dc.relation.volume59en_US
dc.source.urihttps://indianpediatrics.net/nov2022/867.pdfen_US
dc.subjectAsymptomaticen_US
dc.subjectSerologyen_US
dc.subjectSilent diseaseen_US
dc.titleCharacteristics of Siblings With Celiac Disease Diagnosed by Family Screeningen_US
dc.typeJournal Articleen_US
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