Preparation of prospective plant oil derived micro-emulsion vehicles for drug delivery.

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dc.contributor.authorGupta, Syamasrien_US
dc.contributor.authorSanyal, S Ken_US
dc.contributor.authorDatta, Sen_US
dc.contributor.authorMoulik, S Pen_US
dc.date.accessioned2006-08-01en_US
dc.date.accessioned2009-05-27T09:15:28Z
dc.date.available2006-08-01en_US
dc.date.available2009-05-27T09:15:28Z
dc.date.issued2006-08-01en_US
dc.description.abstractBiocompatible oil-in-water (o/w) micro-emulsions can be prospective drug delivery vehicles for their capability to solubilize lipophilic (oil soluble) drugs in the dispersed oil. Plant oils are considered suitable for such a purpose. In this study, we have attempted to examine the dispersion of corn, cottonseed, clove, orange and peppermint oils, as well as isopropyl myristate (IPM) in water continuum in presence of surfactants Tween-20, Brij-30 and Brij-92 and co-surfactants ethanol (EtOH) and isopropyl alcohol (iPrOH). Both ternary (oil/surfactant/water) and psedoternary (oil/surfactant + co-surfactant/water) phase diagrams were constructed. The ternary systems produced larger micro-emulsion forming zones than the psedo-ternary systems. The combinations peppermint oil/iPrOH/water, IPM/iPrOH/water and 1:1 (v/v) peppermint oil + IPM/iPrOH/water were found to form fair proportion of single-phase surfactant-less micro-emulsion. The surfactant-aided ternary systems produced larger clear microemulsion zones, compared to pseudo-ternary systems, while the behaviour of surfactant-less systems was intermediate. The prepared systems had shelf life of 1 year and they withstood temperature variations in the range of 4-40 degrees C.en_US
dc.description.affiliationsyamasri@yahoo.comen_US
dc.identifier.citationGupta S, Sanyal SK, Datta S, Moulik SP. Preparation of prospective plant oil derived micro-emulsion vehicles for drug delivery. Indian Journal of Biochemistry & Biophysics. 2006 Aug; 43(4): 254-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26952
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.mesh2-Propanol --chemistryen_US
dc.subject.meshBiochemistry --methodsen_US
dc.subject.meshBiocompatible Materials --chemistryen_US
dc.subject.meshDrug Carriersen_US
dc.subject.meshDrug Delivery Systems --methodsen_US
dc.subject.meshDrug Stabilityen_US
dc.subject.meshEmulsionsen_US
dc.subject.meshEthanol --pharmacologyen_US
dc.subject.meshOilsen_US
dc.subject.meshPlant Oilsen_US
dc.subject.meshSurface-Active Agents --chemistryen_US
dc.subject.meshTemperatureen_US
dc.subject.meshWateren_US
dc.titlePreparation of prospective plant oil derived micro-emulsion vehicles for drug delivery.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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