Pelvic mature cystic teratoma with neuroendocrine carcinoma: Report of a rare association and review of literature.
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Date
2014-01
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Abstract
Extra-gonadal malignant transformation of teratoma is rare and there are only a
few reports available citing malignancy arising in the non-germ cell components.
We hereby report a case of a 35-year-old female, who presented with lower
backache with a radiologically identifi able mass lesion in the pre-sacral region.
Clinical and radiological fi ndings suggested the possibility of a cystic teratoma.
Histopathological examination and relevant immunohistochemical tests detected
a mature cystic teratoma with features of a grade 2 neuroendocrine tumor in
it. Like the index case, most of the previously reported cases of teratoma with
malignant transformation of the somatic components were found in extra-gonadal
site. This case is being reported to emphasize that any extra-gonadal mass in
reproductive age group, even if it appears radiologically and per-operatively
benign, must be subjected to histopathological examination to rule out possibility
of malignant transformation of the germ cell or non-germ cell components.
Description
Keywords
Extragonadal, malignant transformation, mature cystic teratoma, neuroendocrine tumor, somatic component
Citation
Sable Mukund N, Nath Debojit, Chumbar Sunil, Das Chandan J, Priyadarshini Pratyusha, Kaur Kavneet, Ranjan Richa, Gupta Siddhartha Datta, Das Prasenjit. Pelvic mature cystic teratoma with neuroendocrine carcinoma: Report of a rare association and review of literature. Indian Journal of Pathology & Microbiology. 2014 Jan-Mar 57 (1): 113-115.