Antioxidant Activity and Cytotoxicity in Breast Cancer Cells Line of Mushrooms Extracts; Lentinus polychrous Lev. Compared to Ganoderma lucidum (Fr.) Karst

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dc.contributor.authorNipaporn Armassaen_US
dc.contributor.authorOnanong Poungchompuen_US
dc.contributor.authorSomsak Rayanen_US
dc.contributor.authorSrisupha Leethongen_US
dc.contributor.authorNatthida Weerapreeyakulen_US
dc.contributor.authorSasipawan Machanaen_US
dc.date.accessioned2011-02-20T04:28:49Z
dc.date.available2011-02-20T04:28:49Z
dc.date.created2010-03-14en_US
dc.date.issued2010-03-14en_US
dc.description.abstractThis study examined the antioxidative activity, and cytotoxic effect in breast cancer cell line (MCF-7) of medicinal mushrooms extracts; Lentinus polychrous Lev. and Ganoderma lucidum (Fr.) Karst. Antioxidative activity and cytotoxic effect were determined using the 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) assay and the Neutral red assay, respectively. Results show that G. lucidum extracts from mycelia have antioxidative activity with the DPPH scavenging capacity in the range 1.34\±0.12 and 13.77\±0.98 \µmol/g and the total phenolic compounds in the range 9.91\±2.32 to 119.70\±1.74 mg/100g. L. polychrous Lev. extracts from mycelia had antioxidative activity with the DPPH scavenging capacity in the range 1.33\±1.58 to 11.84\±1.77 \µmol/g and the total phenolic compounds was approximately 10.42\±0.69 to 116.57\±5.27 mg/100g. This study shows that an extract from edible L. polychrous Lev. mushroom extracts exhibited similar antioxidative activity and the total phenolic compounds to the G. lucidum extracts. Moreover, the extract from G. lucidum caused a 50% decrease in breast cancer cell viability with concentration (IC₅₀) of 415.6 \µg/mL. The extract from L. polychrous Lev. mycelia demonstrated IC₅₀ values greater than 500 \µg/mL. It was found that the L. polychrous Lev. Mycelia extract; an edible mushroom in Thailand, possessed radical scavenging activity and the total phenolic content were not different from the G. lucidum extract. Future work on the separation of bioactive compounds contributing to the antioxidant activity and cytotoxicity of the L. polychrous Lev. Mycelia extract should be performed in comparison to the G. lucidum extract.en_US
dc.identifier.citationIsan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสาน; Volume 5 No.3 September-December 2009; 243-250en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/130716
dc.language.isoen_USen_US
dc.publisherIsan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสานen_US
dc.rightsIsan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสานen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/IJPS/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/IJPS/article/view/2239en_US
dc.titleAntioxidant Activity and Cytotoxicity in Breast Cancer Cells Line of Mushrooms Extracts; Lentinus polychrous Lev. Compared to Ganoderma lucidum (Fr.) Karsten_US
dc.typeOriginal Articlesen_US
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