GnRH antagonists in controlled ovarian hyperstimulation protocols in assisted reproductive technique programmes--current concepts.

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dc.contributor.authorJindal, Umesh Nen_US
dc.date.accessioned2006-08-24en_US
dc.date.accessioned2009-05-31T07:41:32Z
dc.date.available2006-08-24en_US
dc.date.available2009-05-31T07:41:32Z
dc.date.issued2006-08-24en_US
dc.description16 references.en_US
dc.description.abstractGonadotrophin (Gn) preparations eg, human menopausal gonadotrophins, follicle stimulating hormone both urinary and recombinant have been highly successful in achieving controlled ovarian hyperstimulation which has become the standard practice in assisted reproductive technique cycles. The fine programming of cycles requires blocking of endogenous luteinising hormone surge, the final ovulation trigger. GnRH analogues, both agonists and antagonists which were developed by substituting amino acids are highly effective in preventing LH surge. Both agonists and antagonists have been developed generating a fierce debate regarding the superiority of one above another. This article is a brief review of literature and attempts to clarify following issues: (a) Major differences between agonists and antagonists. (b) Brief outline of antagonist protocol. (c) Comparative advantages and disadvantages. (d) Use of antagonists in various categories of patients. (e) Future! Can antagonists replace agonists?en_US
dc.description.affiliationGynae and Fertility Research Centre, Chandigarh 160020.en_US
dc.identifier.citationJindal UN. GnRH antagonists in controlled ovarian hyperstimulation protocols in assisted reproductive technique programmes--current concepts. Journal of the Indian Medical Association. 2006 Aug; 104(8): 450, 452, 454 passimen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/97102
dc.language.isoengen_US
dc.source.urihttps://www.jimaonline.org.in/en_US
dc.subject.meshFemaleen_US
dc.subject.meshGonadotropin-Releasing Hormone --antagonists & inhibitorsen_US
dc.subject.meshHormone Antagonists --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshOvarian Hyperstimulation Syndrome --prevention & controlen_US
dc.subject.meshReproductive Techniques, Assisteden_US
dc.titleGnRH antagonists in controlled ovarian hyperstimulation protocols in assisted reproductive technique programmes--current concepts.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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