TT virus infection in acute non-A to E hepatitis in northern Thailand.
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Date
2001-12-04
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Abstract
TT virus is a novel DNA virus widely distributed in the general population. We examined the prevalence of TTV infection in a population with acute non-A to E hepatitis and in comparison groups located in Northern Thailand. The prevalence of TTV in subjects with non-A-E hepatitis was 19% (21/112), 6% (4/72) in healthy volunteers, 17% (12/72) in those with hepatitis A or B, and 17% (8/48) in hospitalized patients with non-hepatitis illnesses. A significant association with TTV infection and non-A-E hepatitis was seen in all groups (OR 3.9, p = 0.02) and in children (OR 25.8, p = 0.001). Among subjects with non-A-E hepatitis, TTV was associated with higher alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels (significant for AST, p = 0.02). Our observations suggest that TTV in our study population may be associated with non-A-E hepatitis and that children in particular may be at risk of hepatocellular injury as a result of TTV infection.
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The Southeast Asian Journal of Tropical Medicine and Public Health.
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Citation
Endy TP, Narupiti S, Myint KS, Suntayakorn S, Kuschner RA, Vaughn DW. TT virus infection in acute non-A to E hepatitis in northern Thailand. The Southeast Asian Journal of Tropical Medicine and Public Health. 2001 Dec; 32(4): 814-22