Immune Reconstitution Inflammatory Syndrome: A Rare Cause of Pleural Effusion in Rifampicin Resistance Non-HIV TB Lymphadenitis Patient
No Thumbnail Available
Date
2024-06
Journal Title
Journal ISSN
Volume Title
Publisher
Jaypee Brothers Medical Publishers Pvt. Ltd.
Abstract
The initiation of anti-tubercular treatment can trigger a pathological hyper-inflammatory response to viable or dead Mycobacterium tuberculosis, known as tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS). Tuberculosis immune reconstitution inflammatory syndrome has been extensively studied in HIV patients and is very rare in non-HIV patients. However, it can occur following corticosteroid withdrawal, discontinuation of anti-TNF therapy, or recovery from neutropenia in non-HIV patients. In non-HIV TB patients, TB-IRIS is particularly rare. The most common manifestation of TB-IRIS in cases of TB lymphadenitis is the development of new lymphadenopathy or the enlargement of pre-existing lymph nodes. Here, we report cases of rifampicin-resistant tubercular lymphadenitis with IRIS presenting with pleural effusion, which completely resolved following steroid therapy.
Description
Keywords
Case report, Immune reconstitution inflammatory syndrome, Rifampicin resistance, TB immune reconstitution inflammatory syndrome, TB lymphadenitis
Citation
Malik Archana, Kumari Pratyaksha, Das Sarthak, Vemuri Mahesh B, Tripathy Saroj . Immune Reconstitution Inflammatory Syndrome: A Rare Cause of Pleural Effusion in Rifampicin Resistance Non-HIV TB Lymphadenitis Patient . The Indian Journal of Chest Diseases and Allied Sciences. 2024 Jun; 66(2): 68-70