Pathological findings in COVID-19: A conventional autopsy-based study from India

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dc.contributor.authorKyada, Hetal C.en_US
dc.contributor.authorBhalara, Rohit V.en_US
dc.contributor.authorVadgama, Divyesh K.en_US
dc.contributor.authorVaru, Pratik R.en_US
dc.contributor.authorTrangadia, Mahesh M.en_US
dc.contributor.authorManvar, Prince J.en_US
dc.contributor.authorBhuva, Shailesh D.en_US
dc.date.accessioned2023-08-19T04:52:08Z
dc.date.available2023-08-19T04:52:08Z
dc.date.issued2022-02
dc.description.abstractBackground & objectives: Autopsy study has been considered the gold standard method for studying the effects of any disease on the body. Since COVID-19 is a novel disease, autopsy is crucial to understand its pathophysiology. This study was conducted to analyze the microscopic and macroscopic findings of various organs in COVID-19 and to associate those findings with clinical observations and laboratory findings. Methods: Conventional invasive autopsies were performed on 33 patients with COVID-19 from September 7, 2020 to December 23, 2020. All the organs were removed by routine dissection techniques and preserved in 10 per cent formalin. The tissues were processed and stained according to standard practices using haematoxylin-eosin (H & E) and periodic acid-schiff (PAS) stain. Results: The study included 28 males and 5 females with a median age of 61 yr (range 30-90 yr). Massive pulmonary oedema and thrombi in the lungs were the characteristic features macroscopically. On microscopic examination, diffuse alveolar damage in the exudative/proliferative phase was found in 29 (87.88%) cases. Among the other notable microscopic findings were bronchopneumonia and lung abscesses due to secondary bacterial infection (n=17, 51.52%), acute tubular injury (n=21, 63.64%) and thrombi in the lungs, heart, and kidneys. Interpretation & conclusions: COVID-19 primarily affected the respiratory and the renal systems in the vast majority of severely affected patients in our study. We also found signs of hypercoagulability, as evidenced by widespread thrombi in multiple organs, along with a raised d-dimer level and a hyperinflammatory state manifested by elevated inflammatory markers. Our autopsy findings and altered laboratory investigations supporten_US
dc.identifier.affiliationsDepartments ofen_US
dc.identifier.affiliationsForensic Medicine &en_US
dc.identifier.affiliationsPathology, Pandit Deendayal Upadhyay Government Medical College, Civil Hospital Campus, Rajkot, Gujarat, Indiaen_US
dc.identifier.citationKyada Hetal C., Bhalara Rohit V., Vadgama Divyesh K., Varu Pratik R., Trangadia Mahesh M., Manvar Prince J., Bhuva Shailesh D.. Pathological findings in COVID-19: A conventional autopsy-based study from India. Indian Journal of Medical Research. 2022 Jan; 155(1): 178-188en_US
dc.identifier.issn0971-5916
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223587
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume155en_US
dc.source.urihttps://doi.org/10.4103/ijmr.IJMR_677_21en_US
dc.subjectAcute tubular injuryen_US
dc.subjectautopsyen_US
dc.subjectdiffuse alveolar damageen_US
dc.subjecthypercoagulabilityen_US
dc.subjecthyperinflammatory stateen_US
dc.subjectSARS-CoV-2en_US
dc.subjectthrombien_US
dc.titlePathological findings in COVID-19: A conventional autopsy-based study from Indiaen_US
dc.typeJournal Articleen_US
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