A Hidden Rarity: Incidental Posterior Mediastinal Neurofibroma with Middle Mediastinal and Lung Parenchymal Extension in a 20-year-old Male with Neurofibromatosis Type 1

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dc.contributor.authorPaul, Ben_US
dc.contributor.authorUpadhya, Pen_US
dc.contributor.authorNadaf, Zen_US
dc.contributor.authorGanesh, RN.en_US
dc.date.accessioned2025-05-09T11:00:45Z
dc.date.available2025-05-09T11:00:45Z
dc.date.issued2024-12
dc.description.abstractNeurofibromatosis type 1 (NF1) is a rare genetic disorder characterized by multiple benign tumors of the nerves and skin, known as neurofibromas. Mediastinal involvement in NF1, particularly with anatomical extension to both posterior and middle mediastinum along with extension into lung parenchyma, is an uncommon occurrence. Here, we present the case of a 20-year-old male with a known history of NF1 who was incidentally found to have a mediastinal mass during a pre-surgical fitness evaluation. Histopathological analysis confirmed the mass to be a neurofibroma. This case highlights the importance of considering neurofibromas in the differential diagnoses of mediastinal masses in patients with NF1, even when they are asymptomatic. The potential risk for malignant transformation into a malignant peripheral nerve sheath tumor (MPNST) warranted surgical intervention and hence the patient was referred to a thoracic surgeon.en_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.citationPaul B, Upadhya P, Nadaf Z, Ganesh RN.. A Hidden Rarity: Incidental Posterior Mediastinal Neurofibroma with Middle Mediastinal and Lung Parenchymal Extension in a 20-year-old Male with Neurofibromatosis Type 1 . The Indian Journal of Chest Diseases and Allied Sciences. 2024 Dec; 66(4): 148-151en_US
dc.identifier.issn0377-9343
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245838
dc.languageenen_US
dc.publisherJaypee Brothers Medical Publishers Pvt. Ltd.en_US
dc.relation.issuenumber4en_US
dc.relation.volume66en_US
dc.source.urihttps://doi.org/10.5005/jp-journals-11007-0133en_US
dc.subjectAsymptomatic mediastinal massen_US
dc.subjectCase reporten_US
dc.subjectLung parenchymal involvementen_US
dc.subjectMediastinal neurofibromaen_US
dc.subjectMultidisciplinary managementen_US
dc.subjectNeurofibromatosis type 1en_US
dc.subjectPlexiform neurofibromaen_US
dc.subjectRare presentationen_US
dc.subjectThoracic neurofibromaen_US
dc.titleA Hidden Rarity: Incidental Posterior Mediastinal Neurofibroma with Middle Mediastinal and Lung Parenchymal Extension in a 20-year-old Male with Neurofibromatosis Type 1en_US
dc.typeJournal Articleen_US
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