Prediction of radiotherapy effect by diffusion-weighted imaging in esophageal carcinoma xenograft model

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dc.contributor.authorZhang, Anduen_US
dc.contributor.authorSu, Xiaohuaen_US
dc.contributor.authorWang, Yanfeien_US
dc.contributor.authorShi, Gao-Fengen_US
dc.contributor.authorHan, Chunen_US
dc.contributor.authorZhang, Junen_US
dc.contributor.authorWang, Lanen_US
dc.contributor.authorZhang, Ruohuien_US
dc.date.accessioned2020-11-18T10:08:19Z
dc.date.available2020-11-18T10:08:19Z
dc.date.issued2020-05
dc.description.abstractAim: This study was to evaluate the value of diffusion-weighted imaging (DWI) in predicting the efficacy of radiotherapy for esophageal cancer from xenograft model level. Subjects and Methods: Thirty-two tumor-bearing mice from the Eca-109 cell line nude mice models were established. The experimental group (n = 16) received a single dose of 15 Gy (6MV X-ray), whereas the control group (n = 16) did not receive any treatment. The tumor volume and apparent diffusion coefficient (ADC) were obtained. The cell density, tissue necrosis ratio, and CD31 expression were determined at matched time points. Results: The tumor volume was smaller in the experimental group than in the control group (P < 0.05) on the 7th day after radiotherapy (1.580 ± 0.965 cm3 vs. 2.671 ± 0.915 cm3). The ADC values were higher in the experimental group than in the control group on the 3rd day (P < 0.05) (998.15 ± 163.76 ×10− 6 mm2/s vs. 833.32 ± 142.15 ×10− 6 mm2/s). On the 3rd day after radiotherapy, the differences in cell density and necrosis ratio between the two groups were statistically significant; the tumor cell density was lower in the experimental group (25.56 ± 1.40%) than in the control group (33.48 ± 4.18%) (P < 0.05), and the proportion of tissue necrosis was higher in the experimental group (32.19 ± 1.21%) than in the control group (29.16 ± 2.16%) (P < 0.05). The negative and weak positive rate of CD31 expression in the experimental group was higher than the control group, whereas the generally positive and strong positive rate of CD31 expression was significantly lower than the control group in the early stage (P < 0.05). Conclusion: ADC values may change at the early stage before the morphological changes of tumors. Changes in cell density and necrosis ratio of transplanted tumors correspond to the changes in ADC values. DWI can be used for the early prediction of esophageal cancer radiotherapy efficacyen_US
dc.identifier.affiliationsDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, Chinaen_US
dc.identifier.affiliationsDepartment of Oncology, Hebei General Hospital, Shijiazhuang, Hebei, Chinaen_US
dc.identifier.affiliationsDepartment of CT and MRI, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, Chinaen_US
dc.identifier.affiliationsDepartment of CT and MRI, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, Chinaen_US
dc.identifier.affiliationsDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, Chinaen_US
dc.identifier.affiliationsDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, Chinaen_US
dc.identifier.affiliationsDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, Chinaen_US
dc.identifier.affiliationsDepartment of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, Chinaen_US
dc.identifier.citationZhang Andu, Su Xiaohua, Wang Yanfei, Shi Gao-Feng, Han Chun, Zhang Jun, Wang Lan, Zhang Ruohui. Prediction of radiotherapy effect by diffusion-weighted imaging in esophageal carcinoma xenograft model. Journal of Cancer Research and Therapeutics. 2020 May; 16(2): 343-349en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213822
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume16en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_627_19en_US
dc.subjectApparent diffusion coefficienten_US
dc.subjectdiffusion‑weighted imagingen_US
dc.subjectesophageal carcinomaen_US
dc.subjectradiotherapyen_US
dc.titlePrediction of radiotherapy effect by diffusion-weighted imaging in esophageal carcinoma xenograft modelen_US
dc.typeJournal Articleen_US
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