Vitamin D and skin diseases: A review.

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dc.contributor.authorWadhwa, Bhawna
dc.contributor.authorRelhan, Vineet
dc.contributor.authorGoel, Khushbu
dc.contributor.authorKochhar, Atul M
dc.contributor.authorGarg, Vijay Kumar
dc.date.accessioned2015-07-18T11:00:34Z
dc.date.available2015-07-18T11:00:34Z
dc.date.issued2015-07
dc.description.abstractVitamin D, originally associated with rickets and osteomalacia, has recently been shown to have a role in a number of medical and dermatological diseases. It has been found that vitamin D receptors and the enzymatic machinery capable of converting circulating 25-hydroxyvitamin D [25(OH)D] to the active 1,25-hydroxyvitamin D [1,25(OH)D] is present in most cells in the body including the skin. It is well known that vitamin D analogs are effective in the treatment of psoriasis vulgaris because of their anti-proliferative and pro-differentiating effects on keratinocytes. However, new roles have been found for vitamin D in skin, such as immunomodulatory and anti-apoptotic effects thus raising a possibility of its use in conditions such as atopic dermatitis and infections. Increasing evidence now indicates that cutaneous vitamin D synthesis may help in prevention of skin malignancies and further, that cancer mortality may be reduced by oral supplementation of vitamin D. Various epidemiological studies have linked low levels of vitamin D to autoimmune diseases including vitiligo, and topical vitamin D has been used to treat vitiligo. This review focuses on a wide array of roles of vitamin D in various skin disorders with emphasis on both its well-established role as in psoriasis and the less characterized role in other disorders such as ichthyosis, tuberculosis or acne.en_US
dc.identifier.citationWadhwa Bhawna, Relhan Vineet, Goel Khushbu, Kochhar Atul M, Garg Vijay Kumar. Vitamin D and skin diseases: A review. Indian Journal of Dermatology, Venereology and Leprology. 2015 Jul-Aug; 81(4): 344-355.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/160051
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2015;volume=81;issue=4;spage=344;epage=355;aulast=Wadhwaen_US
dc.subjectIcthyosisen_US
dc.subjectpsoriasisen_US
dc.subjectvitamin Den_US
dc.subjectvitiligoen_US
dc.subject.meshDermatitis, Atopic --drug therapy
dc.subject.meshHumans
dc.subject.meshIchthyosis --drug therapy
dc.subject.meshPsoriasis --drug therapy
dc.subject.meshSkin Diseases --drug therapy
dc.subject.meshVitamin D --therapeutic use
dc.subject.meshVitiligo --drug therapy
dc.titleVitamin D and skin diseases: A review.en_US
dc.typeArticleen_US
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