Comparative Study Of Oxidant Antioxidants And Inflammatory Markers Between Obese And Non Obese Newly Diagnosed COPD Patients.
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Date
2015-07
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Abstract
COPD has widespread systemic manifestations. Inflammation plays important role in its pathophysiology.
Aim of the present study was to compare markers of oxidative stress and inflammation between obese and
non obese COPD patients. The levels of pro inflammatory cytokines CRP, IL6 and TNF α were compared
between obese and non-obese subjects by applying student’s t test. Oxidative imbalance was assessed by
analyzing MDA and FRAP assay in same subjects. Correlation of BMI with the above study parameters was
analyzed using Pearson’s test. Results indicated that levels of CRP, IL6 and TNF α were elevated in obese
group as compared to non-obese group (p<0.001). Total antioxidant capacity estimated by FRAP assay was
lower (p=0.005) but the levels of oxidants estimated indirectly by MDA was higher (p=0.01) in obese COPD
patients. In all COPD patients included in present study BMI correlated inversely with FRAP (r=-0.546,
p=0.013), FVC (r=0.548, p=0.012) and FEV1 (r=-0.865, p<0.001). Similarly BMI correlated positively with
markers of inflammation namely CRP(r=0.526, p=0.017), IL6(r=0.865, p<0.001), TNF α (r=0.653,p=0.002).
Positive correlation of BMI was found with MDA(r=0.536, p=0.015). Conclusion: there is higher inflammation
in obesity resulting in oxidant antioxidant imbalance and lung function decline.
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Keywords
COPD, obesity, inflammation, total anti oxidant capacity, BMI
Citation
Shah Mohammad Abbas Waseem1, Mohammad Mobarak Hossain2, S. Aijaz Abbas Rizvi2, Najmul Islam3 and Zuber Ahmad4. Comparative Study Of Oxidant Antioxidants And Inflammatory Markers Between Obese And Non Obese Newly Diagnosed COPD Patients. Indian Journal of Physiology and Pharmacology. 2015 Jul-Sept; 59(3): 341-345.