Conformations of hydrophobic peptides in trifluoroethanol, water and in solid state: a circular dichroism and Fourier Transform Infrared study.

Simple item page
dc.contributor.authorJagannadham, M Ven_US
dc.contributor.authorKrishnamurthy, A Sen_US
dc.contributor.authorHusain, Sen_US
dc.contributor.authorNagaraj, Ren_US
dc.date.accessioned1999-12-09en_US
dc.date.accessioned2009-05-27T09:43:55Z
dc.date.available1999-12-09en_US
dc.date.available2009-05-27T09:43:55Z
dc.date.issued1999-12-09en_US
dc.description.abstractThe conformations of peptides corresponding to KLLIALVLCFLPLAALG have been examined in trifluoroethanol (TFE), aqueous medium by circular dichroism spectroscopy and in the solid state by Fourier Transform Infra Red Spectroscopy (FTIR). The 17-residue parent peptide and peptides corresponding to shorter segments LVLCFLPLAALG and CFLPLAALG showed preference for helical conformation in TFE. Even the shorter hydrophobic peptides corresponding to KLLIA and LVL showed propensity for beta-turn conformations in TFE. However, peptides corresponding to the relatively polar segment FLPLAALG were unordered in TFE. In water, peptides that showed ordered conformation in TFE preferred beta-conformation. In solid-state, FTIR spectra indicated that the hydrophobic peptides adopt beta-structures with extensive hydrogen bonded network in the solid-state. The hydrophobic core segment thus appears to dictate the conformational propensity of the peptide.en_US
dc.description.affiliationCentre for Cellular and Molecular Biology, Hyderabad, India.en_US
dc.identifier.citationJagannadham MV, Krishnamurthy AS, Husain S, Nagaraj R. Conformations of hydrophobic peptides in trifluoroethanol, water and in solid state: a circular dichroism and Fourier Transform Infrared study. Indian Journal of Biochemistry & Biophysics. 1999 Dec; 36(6): 422-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28393
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshCircular Dichroismen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPeptides --chemistryen_US
dc.subject.meshProtein Conformationen_US
dc.subject.meshSpectrophotometry, Infrareden_US
dc.subject.meshTrifluoroethanol --chemistryen_US
dc.subject.meshWater --chemistryen_US
dc.titleConformations of hydrophobic peptides in trifluoroethanol, water and in solid state: a circular dichroism and Fourier Transform Infrared study.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Biochemistry & Biophysics