Orally disintegrating tablets: An overview.
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Date
2014-02
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Abstract
Orally disintegrating tablets (ODTs) have greatly increased dosage forms which have remarkable impact on the
patient compliance especially for the pediatric, geriatric and psychiatric patients with deglutition disorders.
Several technologies either conventional or patented based on freeze drying/lyophilization, spray drying,
moulding, phase transition process, melt granulation, sublimation, mass extrusion, cotton candy process, direct
compression etc. have been developed for manufacturing of ODTs. In this review brief information about ODTs
including definition, ideal and desired characteristics, advantages, limitations and disadvantages, drug canditates,
challenges in formulation, excipients with recent developments in superdisintegrants, tast masking,
manufacturing techniques, evaluation parameters and recent patents in ODTs are presentented.
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Keywords
Deglutition disorders, orally disintegrating tablets, excipients, taste masking, patents
Citation
ALĞIN YAPAR Evren. Orally disintegrating tablets: An overview. Journal of Applied Pharmaceutical Science. 2014 Feb; 4(2): 118-125.