Protective effect of propranolol on ethanol-induced gastric lesions in rats: probable mechanism of action.

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dc.contributor.authorRataboli, P Ven_US
dc.contributor.authorBhandare, P Nen_US
dc.contributor.authorD'Souza, R Sen_US
dc.contributor.authorDhume, V Gen_US
dc.date.accessioned1992-01-01en_US
dc.date.accessioned2009-06-01T07:38:01Z
dc.date.available1992-01-01en_US
dc.date.available2009-06-01T07:38:01Z
dc.date.issued1992-01-01en_US
dc.description.abstractThe non-selective beta-adrenoceptor antagonist, propranolol, has been reported to protect against gastric injury in mice, an effect only partly due to prostaglandin release. This study was designed to confirm the gastric cytoprotective effect of propranolol in another species of animal, the rat, and investigate further its mechanism of action. Our results show that propranolol prevents both ethanol-induced gastric lesions as well as ethanol-induced contraction of the circular muscle of rat fundic strip. The local anaesthetic, lignocaine also inhibited the effect of ethanol on circular muscle. However, timolol, another non-selective beta-adrenoceptor antagonist, failed to produce such an action. The effect of propranolol was abolished by the cyclooxygenase inhibitor, indomethacin and a high dose of the guanylate cyclase inhibitor, methylene blue. The results suggest that in addition to prostaglandins, endogenous nitric oxide and the membrane stabilising action of propranolol may also be involved in its gastroprotective action.en_US
dc.description.affiliationDepartment of Pharmacology, Goa Medical College, Tiswadi.en_US
dc.identifier.citationRataboli PV, Bhandare PN, D'Souza RS, Dhume VG. Protective effect of propranolol on ethanol-induced gastric lesions in rats: probable mechanism of action. Indian Journal of Physiology and Pharmacology. 1992 Jan; 36(1): 35-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108303
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshEthanol --antagonists & inhibitorsen_US
dc.subject.meshGastric Fundus --drug effectsen_US
dc.subject.meshGastrointestinal Hemorrhage --chemically induceden_US
dc.subject.meshIndomethacin --pharmacologyen_US
dc.subject.meshLidocaine --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMethylene Blue --pharmacologyen_US
dc.subject.meshMuscle Contraction --drug effectsen_US
dc.subject.meshPropranolol --therapeutic useen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshStomach Diseases --chemically induceden_US
dc.titleProtective effect of propranolol on ethanol-induced gastric lesions in rats: probable mechanism of action.en_US
dc.typeJournal Articleen_US
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