Parvovirus B19 presenting with persistent pancytopenia in a patient of T-ALL post induction chemotherapy diagnosed on bone marrow examination.

Simple item page
dc.contributor.authorGadage, Vijaya S
dc.contributor.authorViswanathan, Seethalakshmi
dc.contributor.authorKunal, Sehgal
dc.contributor.authorSubramanian, P G
dc.contributor.authorGujral, Sumeet
dc.date.accessioned2012-10-11T10:44:19Z
dc.date.available2012-10-11T10:44:19Z
dc.date.issued2011-07
dc.description.abstractManifestations of parvovirus B19 vary even in the normal host from asymptomatic or subclinical infection to a spectrum of illness with symptoms during viremic and immune complex mediated stage of disease. We report the morphological findings of parvovirus B19 infection (confirmed on serology) in a patient of T-acute lymphoblastic lymphoma (T-ALL) who underwent induction phase of chemotherapy (MCP 842 protocol). Persistent pancytopenia in the bone marrow aspirate with mild increase in blasts was thought to be due to failure to achieve marrow remission. However, giant pronormoblasts with prominent intranuclear inclusions confirmed on trephine biopsy led to the suspicion of parvovirus B19 infection which was later confirmed on serology. This case is presented to report the rarely seen classical morphological feature of parvovirus infection on bone marrow examination which was incidentally the first investigation to diagnose the viremic phase of the infection, indicating that a high index of suspicion needs to be kept in mind while examining bone marrows of susceptible patients.en_US
dc.identifier.citationGadage Vijaya S, Viswanathan Seethalakshmi, Kunal Sehgal, Subramanian P G, Gujral Sumeet. Parvovirus B19 presenting with persistent pancytopenia in a patient of T-ALL post induction chemotherapy diagnosed on bone marrow examination. Indian Journal of Pathology & Microbiology. 2011 Jul-Sept 54(3): 603-605.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142056
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=603;epage=605;aulast=Gadageen_US
dc.subjectBone marrowen_US
dc.subjectintranuclear inclusionen_US
dc.subjectpancytopeniaen_US
dc.subjectparvovirus B19en_US
dc.subject.meshAdult
dc.subject.meshAntineoplastic Agents --administration & dosage
dc.subject.meshBone Marrow --pathology
dc.subject.meshBone Marrow Examination
dc.subject.meshHistocytochemistry
dc.subject.meshHumans
dc.subject.meshInduction Chemotherapy --methods
dc.subject.meshMale
dc.subject.meshMicroscopy
dc.subject.meshPancytopenia --diagnosis
dc.subject.meshPancytopenia --etiology
dc.subject.meshParvoviridae Infections --complications
dc.subject.meshParvoviridae Infections --diagnosis
dc.subject.meshParvoviridae Infections --pathology
dc.subject.meshParvoviridae Infections --virology
dc.subject.meshParvovirus B19, Human --isolation & purification
dc.subject.meshParvovirus B19, Human --pathogenicity
dc.subject.meshPrecursor T-Cell Lymphoblastic Leukemia-Lymphoma --complications
dc.subject.meshPrecursor T-Cell Lymphoblastic Leukemia-Lymphoma --drug therapy
dc.titleParvovirus B19 presenting with persistent pancytopenia in a patient of T-ALL post induction chemotherapy diagnosed on bone marrow examination.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijpm2011v54n3p603.pdf
Size:
900.06 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Pathology & Microbiology