The genetics of diabetes mellitus.

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dc.contributor.authorRadha, Ven_US
dc.contributor.authorVimaleswaran, K Sen_US
dc.contributor.authorDeepa, Ren_US
dc.contributor.authorMohan, Ven_US
dc.date.accessioned2003-06-30en_US
dc.date.accessioned2009-05-27T08:37:51Z
dc.date.available2003-06-30en_US
dc.date.available2009-05-27T08:37:51Z
dc.date.issued2003-06-30en_US
dc.description85 references.en_US
dc.description.abstractGenes play an important role in the development of diabetes mellitus. Putative susceptibility genes could be the key to the development of diabetes. Type 1 diabetes mellitus is one of the most common chronic diseases of childhood. A combination of genetic and environmental factors is most likely the cause of Type 1 diabetes. The pathogenetic sequence leading to the selective autoimmune destruction of islet beta-cells and development of Type 1 diabetes involves genetic factors, environmental factors, immune regulation and chemical mediators. Unlike Type 1 diabetes mellitus, Type 2 diabetes is often considered a polygenic disorder with multiple genes located on different chromosomes being associated with this condition. This is further complicated by numerous environmental factors which also contribute to the clinical manifestation of the disorder in genetically predisposed persons. Only a minority of cases of type 2 diabetes are caused by single gene defects such as maturity onset diabetes of the young (MODY), syndrome of insulin resistance (insulin receptor defect) and maternally inherited diabetes and deafness (mitochondrial gene defect). Although Type 2 diabetes mellitus appears in almost epidemic proportions our knowledge of the mechanism of this disease is limited. More information about insulin secretion and action and the genetic variability of the various factors involved will contribute to better understanding and classification of this group of diseases. This article discusses the results of various genetic studies on diabetes with special reference to Indian population.en_US
dc.description.affiliationMadras Diabetes Research Foundation & M. V. Diabetes Specialities Centre, Chennai, India.en_US
dc.identifier.citationRadha V, Vimaleswaran KS, Deepa R, Mohan V. The genetics of diabetes mellitus. Indian Journal of Medical Research. 2003 Jun; 117(): 225-38en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/25110
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshDiabetes Mellitus --geneticsen_US
dc.subject.meshDiabetes Mellitus, Type 1 --geneticsen_US
dc.subject.meshDiabetes Mellitus, Type 2 --geneticsen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHLA Antigens --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshModels, Biologicalen_US
dc.titleThe genetics of diabetes mellitus.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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