Cardiac nociception induced rectal response: relation with haemodynamic changes.

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dc.contributor.authorKoley, Jen_US
dc.contributor.authorBasak, A Ken_US
dc.contributor.authorDas, Men_US
dc.contributor.authorKoley, Ben_US
dc.date.accessioned1998-04-04en_US
dc.date.accessioned2009-06-01T05:47:03Z
dc.date.available1998-04-04en_US
dc.date.available2009-06-01T05:47:03Z
dc.date.issued1998-04-04en_US
dc.description.abstractEpicardial application of nicotine (200 micrograms/ml) over the left ventricle or occlusion of the left anterior descending coronary artery (LAD) in lightly anaesthetised cats resulted a biphasic change in rectal motility-initial relaxation followed by contraction along with biphasic changes of blood pressure (B.P.) with epicardial nicotine and only hypotension with LAD occlusion. Desensitisation of ventricular receptors by epicardial application of 2% lignocaine abolished the rectal response and the biphasic blood pressure response but not the LAD occlusion induced hypotension. Sectioning of left inferior cardiac nerve (LICN) abolished such cardiorectal reflex but not the B.P. changes. Stimulation of central cut end of LICN elicited similar cardiorectal reflex keeping the B.P. unaltered. Atropinization (1 mg/kg) abolished only the contractile phase of the cardiorectal reflex and also the hypotension induced by epicardial nicotine. Intra-arterial NG-nitro-L-Arginine (LNNA) at a dose of 2 mg/kg abolished the relaxation phase of such cardiorectal reflex keeping the B.P. changes unaltered. LAD occlusion induced hypotension was neither counteracted by atropine nor by LNNA pretreatment. These indicate that though the cardio-rectal reflexes are associated with B.P. changes, they do not have any direct correlation.en_US
dc.description.affiliationDepartment of Physiology, University College of Science, Calcutta.en_US
dc.identifier.citationKoley J, Basak AK, Das M, Koley B. Cardiac nociception induced rectal response: relation with haemodynamic changes. Indian Journal of Physiology and Pharmacology. 1998 Apr; 42(2): 259-65en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106879
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtropine --pharmacologyen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshCatsen_US
dc.subject.meshCoronary Vessels --physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal Motility --physiologyen_US
dc.subject.meshHeart --drug effectsen_US
dc.subject.meshHemodynamics --drug effectsen_US
dc.subject.meshHypotension --physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNicotine --pharmacologyen_US
dc.subject.meshNicotinic Agonists --pharmacologyen_US
dc.subject.meshNitroarginine --pharmacologyen_US
dc.subject.meshNociceptors --physiologyen_US
dc.subject.meshPericardium --drug effectsen_US
dc.subject.meshRectum --blood supplyen_US
dc.subject.meshVentricular Function, Left --drug effectsen_US
dc.titleCardiac nociception induced rectal response: relation with haemodynamic changes.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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