Carbapenemases: The New Face of Antimicrobial Resistance.
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Date
2012-06
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Abstract
With the advent of antibiotics, a new era ushered in bringing within its folds, a strong defense against the invading deadly
microorganisms. This phenomenon is referred to as antimicrobial resistance. Carbapenemases are b-lactamases which hydrolyse
carbapenems. The enzyme, New Delhi metallo-beta-lactamase (NDM-1) breaks this ring, rendering the drug ineffective.
NDM-1 producing bacteria are resistant to many existing antibiotics including carbapenems - a class of drug often reserved for
emergency use and last resort treatment.
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Keywords
Antimicrobial resistance, carbapenems, carbapenemases, b-lactamases, NDM-1
Citation
Malhotra Kriti, Walia Rani, Aslam Shafiqua, Goyal Manoj. Carbapenemases: The New Face of Antimicrobial Resistance. Indian Journal of Clinical Practice. 2012 June; 23(1): 6-10.