Multiple myeloma presenting with coexisting severe marrow hypoplasia.

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dc.contributor.authorMedhi, Ken_US
dc.contributor.authorKalita, Diptien_US
dc.contributor.authorChopra, Anitaen_US
dc.contributor.authorAnand, Monaen_US
dc.contributor.authorRaina, Vinoden_US
dc.contributor.authorKumar, Rajiveen_US
dc.date.accessioned2008-10-15en_US
dc.date.accessioned2009-05-29T12:22:09Z
dc.date.available2008-10-15en_US
dc.date.available2009-05-29T12:22:09Z
dc.date.issued2008-10-15en_US
dc.description.abstractA 68-year-old man was referred to us with clinical and bone marrow (BM) features compatible with aplastic anemia. The correct diagnosis, hypoplasia of the BM coexisting with multiple myeloma, became apparent after noting rouleaux in the peripheral blood (PB) and approximately 50% plasma cells in the touch imprint of one of the two BM biopsies done. As standard therapy was precluded, the patient was put on dexamethasone but died within 4 days. This first case of the coexistence of untreated myeloma with aplastic BM shows that even apparently straightforward hypoplasia seen on the BM biopsy should be interpreted in conjunction with the PB smear and the BM touch imprint findings. Among other things, the BM biopsy and imprint should be repeated if the PB has findings such as rouleaux that do not fit with straightforward aplastic anemia. The combination of myeloma and BM aplasia precludes standard therapy and is rapidly fatal.en_US
dc.description.affiliationLaboratory Oncology Unit, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110 029, India.en_US
dc.identifier.citationMedhi K, Kalita D, Chopra A, Anand M, Raina V, Kumar R. Multiple myeloma presenting with coexisting severe marrow hypoplasia. Indian Journal of Pathology & Microbiology. 2008 Oct-Dec; 51(4): 543-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74517
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAgeden_US
dc.subject.meshBone Marrow --pathologyen_US
dc.subject.meshBone Marrow Neoplasms --pathologyen_US
dc.subject.meshFatal Outcomeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMultiple Myeloma --pathologyen_US
dc.titleMultiple myeloma presenting with coexisting severe marrow hypoplasia.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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