Unscrewing the DHT-Blocking Properties of Allium cepa Extract: Virtual Screening of Active Compounds Against 5-Alpha Reductase and Evaluation of ADME/T Properties of Compounds

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dc.contributor.authorAlam, Mudassiren_US
dc.contributor.authorAbbas, Kashifen_US
dc.date.accessioned2023-08-19T04:54:37Z
dc.date.available2023-08-19T04:54:37Z
dc.date.issued2023-07
dc.description.abstractAndrogenetic alopecia (AGA) occurs in genetically prone men and women and is defined by pattern-related, non-scarring hair follicle shrinkage. It is estimated that up to 80% of men and 50% of women will be affected by AGA at some stage in their lives. The underlying pathophysiology may be traced back to the enzyme 5-alpha-reductase, which is responsible for the conversion of testosterone to dihydrotestosterone (DHT), a more powerful androgen, and its accumulation in hair follicles leads to hair loss. The therapeutic approach for treating AGA mainly relies on the inhibition of 5-alpha- reductase. Allium cepa (onion) extract is in trend as a natural remedy for the treatment of AGA. The study aims at in-silico and ADME/T analysis of active compounds present in onion extract against 5-alpha-reductase to evaluate and visualize protein-ligand interaction.en_US
dc.identifier.affiliationsAligarh Muslim University, Aligarh, Uttar Pradesh, India.en_US
dc.identifier.citationAlam Mudassir, Abbas Kashif. Unscrewing the DHT-Blocking Properties of Allium cepa Extract: Virtual Screening of Active Compounds Against 5-Alpha Reductase and Evaluation of ADME/T Properties of Compounds. Indian Journal of Pharmaceutical & Biological Research. 2023 Jul; 11(2): 5-9en_US
dc.identifier.issn2320-9267
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223777
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltden_US
dc.relation.issuenumber2en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.30750/ijpbr.11.2.02en_US
dc.subjectAndrogenetic alopeciaen_US
dc.subjectDHTen_US
dc.subjectFinasterideen_US
dc.subjectOnion extracten_US
dc.subject5-alpha reductase.en_US
dc.titleUnscrewing the DHT-Blocking Properties of Allium cepa Extract: Virtual Screening of Active Compounds Against 5-Alpha Reductase and Evaluation of ADME/T Properties of Compoundsen_US
dc.typeJournal Articleen_US
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