Effect of metformin on renal microsomal proteins, lipid peroxidation and antioxidant status in dexamethasone-induced type-2 diabetic mice.

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dc.contributor.authorJatwa, Rameshwar
dc.contributor.authorKar, Anand
dc.date.accessioned2011-11-14T03:56:06Z
dc.date.available2011-11-14T03:56:06Z
dc.date.issued2010-02
dc.description.abstractAn SDS-PAGE analysis of renal microsomal fraction of albino mice was performed to study the involvement of proteins in dexamethasone-induced type-2 diabetes mellitus (DM) and their alterations by metformin, a widely accepted oral antidiabetic drug. In addition, changes in renal lipid peroxidation (LPO), activities of superoxide dismutase (SOD) and catalase (CAT), reduced glutathione (GSH) content, as well as renal somatic index (RSI) and daily rate of water consumption were also investigated. While dexamethasone administration (1.0 mg/kg for 21 days) expressed two renal proteins (43 kDa and 63.23 kDa), in addition to the increased fasting serum levels of glucose and insulin, renal LPO, RSI and daily rate of water consumption, a parallel decrease in renal SOD, CAT and GSH was also observed. Treatment with metformin normalized these alterations including the renal proteins and LPO, confirming its efficacy in ameliorating dexamethasone-induced type-2 DM and also the association of two proteins with type-2 DM.en_US
dc.identifier.citationJatwa Rameshwar, Kar Anand. Effect of metformin on renal microsomal proteins, lipid peroxidation and antioxidant status in dexamethasone-induced type-2 diabetic mice. Indian Journal of Biochemistry & Biophysics. 2010 Feb; 47(1): 44-48.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135242
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/7461/1/IJBB%2047%281%29%2044-48.pdfen_US
dc.subjectDexamethsoneen_US
dc.subjectLipid peroxidationen_US
dc.subjectMetforminen_US
dc.subjectMiceen_US
dc.subjectSDS-PAGEen_US
dc.subject.meshAnimals
dc.subject.meshCatalase --metabolism
dc.subject.meshDexamethasone
dc.subject.meshDiabetes Mellitus, Experimental --metabolism
dc.subject.meshDiabetes Mellitus, Type 2 --metabolism
dc.subject.meshGlutathione --metabolism
dc.subject.meshHypoglycemic Agents --pharmacology
dc.subject.meshKidney --drug effects
dc.subject.meshKidney --enzymology
dc.subject.meshKidney --metabolism
dc.subject.meshMale
dc.subject.meshMetformin --pharmacology
dc.subject.meshMice
dc.subject.meshMicrosomes --drug effects
dc.subject.meshMicrosomes --enzymology
dc.subject.meshMicrosomes --metabolism
dc.subject.meshRadioimmunoassay
dc.subject.meshSuperoxide Dismutase --metabolism
dc.titleEffect of metformin on renal microsomal proteins, lipid peroxidation and antioxidant status in dexamethasone-induced type-2 diabetic mice.en_US
dc.typeArticleen_US
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