Overall and Event Free Survival of Childhood Cancer - Report From a Hospital-based Cancer Registry in Northern India, 2013-21

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dc.contributor.authorArora, Ramandeep Singhen_US
dc.contributor.authorKumari, Rashmien_US
dc.contributor.authorAdhana, Arunen_US
dc.contributor.authorTripathi, Rashien_US
dc.contributor.authorSachdev, Mansien_US
dc.contributor.authorJain, Prachien_US
dc.date.accessioned2023-08-25T06:39:59Z
dc.date.available2023-08-25T06:39:59Z
dc.date.issued2023-07
dc.description.abstractObjectives: Using data from a hospital-based cancer registry (HBCR) in the private sector in Northern India, we provide overall survival (OS) and event-free survival (EFS) for childhood cancer patients. Methods: All newly diagnosed childhood (age <18 years) cancer patients in our HBCR registered between March 1, 2013 till July 31, 2021 were eligible. 3-year and 5-year OS (death was an event), EFSc (death, progression/relapse was an event), and EFSa (death, progression/relapse, abandonment of treatment was an event) were calculated using the Kaplan-Meier method. Regression analysis was done to see their association with demographic, diagnostic and treatment variables. Results: 705 newly diagnosed children (36.2% female) with cancer were registered. Common cancers were leukemias (26%), CNS tumors (20%) and bone tumors (16%). 202 (28.6%) had experienced an event at median follow up of 1.95 years (range 0-8.14 years), which included 23 (3.3%) who abandoned treatment. The 3- year OS, EFSc, EFSa were 70.8%, 64.4% and 63.6%, respectively. Correspondingly, 5-year OS, EFSc, EFSa were 66%, 58.6% and 57.5%, respectively. There was no significant difference by age group, gender, nationality, and if cancer directed treatment initiated elsewhere. The OS, EFSa and EFSc by the main and the extended International Childhood Cancer Classification categories varied significantly (P<0.001). Conclusion: We add more recent registry-based OS data on childhood cancer in India and present the first estimates on EFS.en_US
dc.identifier.affiliationsPediatric Oncology Disease Management Group, Max Institute of Cancer Care, Max Super Speciality Hospital, Saket, New Delhien_US
dc.identifier.affiliationsQuality Care Research and Impact, Cankids, New Delhi, Indiaen_US
dc.identifier.affiliationsPediatric Hematology/Oncology and BMT, Burjeel Medical City, Abu Dhabi, UAEen_US
dc.identifier.affiliationsPediatric Oncology Disease Management Group, Max Institute of Cancer Care, Max Super Speciality Hospital, Patparganj, New Delhi, India.en_US
dc.identifier.citationArora Ramandeep Singh, Kumari Rashmi, Adhana Arun, Tripathi Rashi, Sachdev Mansi, Jain Prachi. Overall and Event Free Survival of Childhood Cancer - Report From a Hospital-based Cancer Registry in Northern India, 2013-21. Indian Pediatrics. 2023 Jul; 60(7): 531-536en_US
dc.identifier.issn0079-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225434
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber7en_US
dc.relation.volume60en_US
dc.source.urihttps://indianpediatrics.net/july2023/531.pdfen_US
dc.subjectManagementen_US
dc.subjectOutcomeen_US
dc.subjectSurvival analysis.en_US
dc.titleOverall and Event Free Survival of Childhood Cancer - Report From a Hospital-based Cancer Registry in Northern India, 2013-21en_US
dc.typeJournal Articleen_US
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