Incidence and determinants of left ventricular ejection fraction (LVEF) recovery in heart failure with reduced ejection fraction (HFrEF) of non-ischemic aetiology; a hospital-based prospective longitudinal registry study

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dc.contributor.authorKumar, Sanjeeven_US
dc.contributor.authorNegi, Prakash Chanden_US
dc.contributor.authorAsotra, Sanjeeven_US
dc.contributor.authorKumar, Jitenderen_US
dc.contributor.authorMerwah, Rajeeven_US
dc.contributor.authorSharma, Rajeshen_US
dc.contributor.authorKumar, Riteshen_US
dc.contributor.authorBhardwaj, Vinayen_US
dc.contributor.authorThakur, Preetam Singhen_US
dc.date.accessioned2025-08-13T11:15:20Z
dc.date.available2025-08-13T11:15:20Z
dc.date.issued2025-06
dc.description.abstractBackground: Heart failure with reduced ejection fraction (HFrEF) can show recovery in some patients, especially with non-ischemic causes, leading to better outcomes. Recovery varies due to factors like aetiology and severity of myocardial injury. This study examines the incidence and predictors of left ventricular ejection fraction (LVEF) recovery in non-ischemic HFrEF patients. Methods: This was a prospective observational study conducted at a tertiary care hospital, involving 500 patients with non-ischemic HFrEF (baseline LVEF <40 %). Patients were followed for a duration of 8 years (2011–2023) with periodic clinical assessments and annual echocardiographic evaluations. Data on comorbidities, baseline cardiac function, medication adherence, and clinical events were collected. The incidence rate of LVEF recovery was determined, and Kaplan–Meier survival analysis was used to identify recovery trends over time. Predictors of recovery were evaluated using Cox proportional hazards models. Results: Cumulative incidence of LVEF recovery was 27.4 % (95 % CI: 23.7–31.5) at 8 years, with an incidence rate of 4.5 per 100 person-years. Higher baseline LVEF (?30 %) strongly predicted recovery (HR: 2.17, p < 0.001), while dilated LV (LVEDD ?60 mm, HR: 0.6, p = 0.02) and diabetes (HR: 0.36, p = 0.01) were associated with lower recovery. Education (?Class 5) was linked to better recovery (HR: 1.45, p = 0.04). Beta-blockers showed a potential but nonsignificant benefit. Conclusion: Nearly one-fourth (27.4 %) of patients achieved LVEF recovery over 8 years, with higher baseline LVEF and education associated with better outcomes, while adverse cardiac remodeling and diabetes were linked to lower recovery.en_US
dc.identifier.affiliationsDepartment of Cardiology, IGMC, Shimla, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, IGMC, Shimla, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, IGMC, Shimla, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, IGMC, Shimla, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, IGMC, Shimla, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, IGMC, Shimla, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, IGMC, Shimla, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, IGMC, Shimla, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, IGMC, Shimla, Indiaen_US
dc.identifier.citationKumar Sanjeev, Negi Prakash Chand, Asotra Sanjeev, Kumar Jitender, Merwah Rajeev, Sharma Rajesh, Kumar Ritesh, Bhardwaj Vinay, Thakur Preetam Singh. Incidence and determinants of left ventricular ejection fraction (LVEF) recovery in heart failure with reduced ejection fraction (HFrEF) of non-ischemic aetiology; a hospital-based prospective longitudinal registry study. Indian Heart Journal. 2025 Jun; 77(3): 188-192en_US
dc.identifier.issn0019-4832
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253338
dc.languageenen_US
dc.publisherElsevieren_US
dc.relation.issuenumber3en_US
dc.relation.volume77en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2025.03.016en_US
dc.subjectHeart failureen_US
dc.subjectLeft ventricular ejection fractionen_US
dc.subjectHeart failure with reduced ejection fractionen_US
dc.subjectGuideline-directed medical therapyen_US
dc.subjectCoronary artery diseaseen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.titleIncidence and determinants of left ventricular ejection fraction (LVEF) recovery in heart failure with reduced ejection fraction (HFrEF) of non-ischemic aetiology; a hospital-based prospective longitudinal registry studyen_US
dc.typeJournal Articleen_US
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