Effect of cadmium and captopril on serum angiotensin converting enzyme activity in rats.

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dc.contributor.authorPuri, V Nen_US
dc.date.accessioned1997-05-01en_US
dc.date.accessioned2009-05-27T04:25:01Z
dc.date.available1997-05-01en_US
dc.date.available2009-05-27T04:25:01Z
dc.date.issued1997-05-01en_US
dc.description.abstractThe effects of captopril (2 mg/kg i.p.) and cadmium (1 mg/kg i.p.) at three different time points (30, 60, 180 min) on serum angiotensin converting enzyme (ACE), blood pressure (BP) and heart rate (HR) were examined in male Sprague-Dawley rats. Captopril produced significant inhibition of ACE at 60 and 120 minutes, while maximum fall of BP (15 mm Hg) was obtained at 30 minutes post-test drug treatment. Heart rate at the three different time intervals did not change significantly. ACE levels in the serum were significantly reduced at different time intervals (30, 60, 120 min) in the cadmium-treated group as compared with controls (p < 0.05). Cadmium increased the blood pressure and heart rate of rats. The results indicate that while both cadmium and captopril produce different effects on blood pressure and heart rate, both of these also inhibit the serum ACE in rats.en_US
dc.description.affiliationDivision of Pharmacology, Central Drug Research Institute, Lucknow.en_US
dc.identifier.citationPuri VN. Effect of cadmium and captopril on serum angiotensin converting enzyme activity in rats. Indian Heart Journal. 1997 May-Jun; 49(3): 297-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/4903
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAngiotensin-Converting Enzyme Inhibitors --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshCadmium --pharmacologyen_US
dc.subject.meshCaptopril --pharmacologyen_US
dc.subject.meshHeart Rate --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshPeptidyl-Dipeptidase A --blooden_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshTime Factorsen_US
dc.titleEffect of cadmium and captopril on serum angiotensin converting enzyme activity in rats.en_US
dc.typeJournal Articleen_US
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