Antimicrobial resistance of 100 serial gram-negative isolates in two intensive care units.

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dc.contributor.authorLeelarasamee, Aen_US
dc.contributor.authorJanyapoon, Ken_US
dc.date.accessioned2009-05-27T20:24:06Z
dc.date.available2009-05-27T20:24:06Z
dc.date.issued1992-12-01en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractTo determine antimicrobial resistance pattern among gram-negative bacteria isolated from suspected sources of infections in patients hospitalized in two Intensive Care Units (ICUs) at Siriraj Hospital from September 1991 to December 1991, minimal inhibitory concentrations of one-hundred consecutive gram-negative isolates for various antimicrobials were performed using the microbroth dilution method. Of all gram-negative bacterial isolates, 25 per cent were Pseudomonas aeruginosa, 22 per cent Acinetobacter anitratus, 16 per cent Klebsiella pneumoniae, 12 per cent enterobacter, 8 per cent E.coli, 5 per cent non-fermenter, 4 per cent pseudomonas, 3 per cent arizona, 2 per cent A. lwoffii, 1 per cent Aeromonas hydrophila, 1 per cent Aeromonas hydrophila, 1 per cent Proteus rettgeri, and 1 per cent shigella. The in vitro MIC study revealed that 50, 48, 43, 61, 59, 34, 47, 52, 31, 15 per cent of gram-negative isolates were resistant to gentamicin, tobramycin, amikacin, cefotaxime, ceftriaxone, ceftazidime, aztreonam, piperacillin, ciprofloxacin and imipenem respectively. In addition, 64 and 71 per cent of the isolates were resistant to aminoglycosides and cephalosporins being used in the same patients 48 hours before cultures were obtained respectively. The possible spread of resistant gram-negative isolates by cross contamination was not evident by looking at MIC co-variation in sequential isolates of P. aeruginosa. It was concluded that antimicrobial resistance was highly prevalent among gram-negative bacteria isolated from patients already hospitalized in the ICUs. Potent antimicrobials such as imipenem, newer fluoro-quinolones, ceftazidime and amikacin, are often needed for therapy of serious gram-negative bacterial infections in the ICUs.en_US
dc.description.affiliationDepartment of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationLeelarasamee A, Janyapoon K. Antimicrobial resistance of 100 serial gram-negative isolates in two intensive care units. Journal of the Medical Association of Thailand. 1992 Dec; 75(12): 680-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/42929
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshGram-Negative Bacteria --drug effectsen_US
dc.subject.meshGram-Negative Bacterial Infections --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshIntensive Care Unitsen_US
dc.subject.meshPseudomonas aeruginosa --drug effectsen_US
dc.subject.meshThailanden_US
dc.titleAntimicrobial resistance of 100 serial gram-negative isolates in two intensive care units.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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