Neuropathological spectrum of Rasmussen encephalitis.

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dc.contributor.authorDeb, Prabalen_US
dc.contributor.authorSharma, Mehar Chanden_US
dc.contributor.authorGaikwad, Shaileshen_US
dc.contributor.authorTripathi, Manjarien_US
dc.contributor.authorChandra, P Sharaten_US
dc.contributor.authorJain, Satishen_US
dc.contributor.authorSarkar, Chitraen_US
dc.date.accessioned2005-06-13en_US
dc.date.accessioned2009-06-03T12:41:18Z
dc.date.available2005-06-13en_US
dc.date.available2009-06-03T12:41:18Z
dc.date.issued2005-06-13en_US
dc.description.abstractBACKGROUND: Rasmussen encephalitis (RE) is a chronic epileptic disorder of unknown etiology, and is clinically characterized by progressive neurological deterioration, focal seizures often progressing to intractable epilepsy, cognitive decline and hemispheric atrophy. AIMS: We report the spectrum of neuropathological changes seen in RE, and discuss the evolutionary mechanisms of this disease. MATERIALS AND METHODS: Surgically obtained specimens from RE patients diagnosed during 2002-2004 at this institute were evaluated for the presence and extent of different histopathological features of RE. The H&E and immunohistochemistry stained slides were also evaluated for the type and distribution pattern of inflammatory infiltrates, along with a semiquantitative evaluation for the severity of inflammation. RESULTS: Four cases of RE were admitted during the study period, all of which presented with partial seizures with successive deterioration to intractable epilepsy. The age at onset varied between 5 and 10 years (mean 7.8 years), with three male and one female patients. Subsequently, all four patients underwent hemispherotomy. Histopathological features of perivascular lymphocytic infiltrate, neuronal loss, microglial nodules, and reactive astrocytosis, with or without evidence of neuronophagia confirmed a diagnosis of RE. These cases also had varying degrees of T-cell-rich (CD3-positive) inflammatory infiltrates and CD68-immunopositive microglial proliferation. It was observed that the severity of inflammation had a trend to inversely correlate with the duration of symptoms. CONCLUSION: It is proposed that an accurate evaluation and histopathological grading of these lesions may possibly have a role in patient prognostication.en_US
dc.description.affiliationDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, India.en_US
dc.identifier.citationDeb P, Sharma MC, Gaikwad S, Tripathi M, Chandra PS, Jain S, Sarkar C. Neuropathological spectrum of Rasmussen encephalitis. Neurology India. 2005 Jun; 53(2): 156-60; discussion 160-1en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/121718
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshBrain --pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshEncephalitis --pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation --pathologyen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.titleNeuropathological spectrum of Rasmussen encephalitis.en_US
dc.typeJournal Articleen_US
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