Neurospora crassa fmf-1 encodes the homologue of the Schizosaccharomyces pombe Ste11p regulator of sexual development.
dc.contributor.author | Iyer, Srividhya V | en_US |
dc.contributor.author | Ramakrishnan, Mukund | en_US |
dc.contributor.author | Kasbekar, Durgadas P | en_US |
dc.date.accessioned | 2009-04-07 | en_US |
dc.date.accessioned | 2009-06-02T07:23:39Z | |
dc.date.available | 2009-04-07 | en_US |
dc.date.available | 2009-06-02T07:23:39Z | |
dc.date.issued | 2009-04-07 | en_US |
dc.description.abstract | The Neurospora crassa fmf-1 mutation exerts an unusual 'perithecium-dominant' developmental arrest; fmf-1 x fmf-1+ cross becomes arrested in perithecial development regardless of whether the mutant participates in the cross as the male or female parent. We localized fmf-1 to the LG IL genome segment between the centromere-proximal breakpoint of the chromosome segment duplication Dp(IL)39311 and the centromere. By mapping crossovers with respect to RFLP markers in this region we further localized fmf-1 to an approximately 34-kb-genome segment. Partial sequencing of this segment revealed a point mutation in the gene NCU 09387.1, a homologue of the Schizosaccharomyces pombe ste11+ regulator of sexual development. The fmf-1 mutation did not complement a NCU 09387.1 deletion mutation, and transformation with wild-type NCU 09387.1 complemented fmf-1. S. pombe Ste11 protein (Ste11p) is a transcription factor required for sexual differentiation and for the expression of genes required for mating pheromone signalling in matP and matM cells. If FMF-1 also plays a corresponding role in mating pheromone signalling in Neurospora, then protoperithecia in an fmf-1 x fmf-1+ cross would be unable to either send or receive sexual differentiation signals and thus become arrested in development. | en_US |
dc.description.affiliation | Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India. kas@ccmb.res.in. | en_US |
dc.identifier.citation | Iyer SV, Ramakrishnan M, Kasbekar DP. Neurospora crassa fmf-1 encodes the homologue of the Schizosaccharomyces pombe Ste11p regulator of sexual development. Journal of Genetics. 2009 Apr; 88(1): 33-9 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/114423 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.ias.ac.in/jgenet/index.html | en_US |
dc.subject.mesh | Fungal Proteins --genetics | |
dc.subject.mesh | Fungal Proteins --metabolism | |
dc.subject.mesh | Gene Expression Regulation, Fungal | |
dc.subject.mesh | Genome, Fungal | |
dc.subject.mesh | Models, Genetic | |
dc.subject.mesh | Mutation | |
dc.subject.mesh | Neurospora crassa --genetics | |
dc.subject.mesh | Schizosaccharomyces --genetics | |
dc.subject.mesh | Schizosaccharomyces pombe Proteins --genetics | |
dc.subject.mesh | Transcription Factors --genetics | |
dc.subject.mesh | Transcription Factors --metabolism | |
dc.title | Neurospora crassa fmf-1 encodes the homologue of the Schizosaccharomyces pombe Ste11p regulator of sexual development. | en_US |
dc.type | Journal Article | en_US |
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