Neurospora crassa fmf-1 encodes the homologue of the Schizosaccharomyces pombe Ste11p regulator of sexual development.

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dc.contributor.authorIyer, Srividhya Ven_US
dc.contributor.authorRamakrishnan, Mukunden_US
dc.contributor.authorKasbekar, Durgadas Pen_US
dc.date.accessioned2009-04-07en_US
dc.date.accessioned2009-06-02T07:23:39Z
dc.date.available2009-04-07en_US
dc.date.available2009-06-02T07:23:39Z
dc.date.issued2009-04-07en_US
dc.description.abstractThe Neurospora crassa fmf-1 mutation exerts an unusual 'perithecium-dominant' developmental arrest; fmf-1 x fmf-1+ cross becomes arrested in perithecial development regardless of whether the mutant participates in the cross as the male or female parent. We localized fmf-1 to the LG IL genome segment between the centromere-proximal breakpoint of the chromosome segment duplication Dp(IL)39311 and the centromere. By mapping crossovers with respect to RFLP markers in this region we further localized fmf-1 to an approximately 34-kb-genome segment. Partial sequencing of this segment revealed a point mutation in the gene NCU 09387.1, a homologue of the Schizosaccharomyces pombe ste11+ regulator of sexual development. The fmf-1 mutation did not complement a NCU 09387.1 deletion mutation, and transformation with wild-type NCU 09387.1 complemented fmf-1. S. pombe Ste11 protein (Ste11p) is a transcription factor required for sexual differentiation and for the expression of genes required for mating pheromone signalling in matP and matM cells. If FMF-1 also plays a corresponding role in mating pheromone signalling in Neurospora, then protoperithecia in an fmf-1 x fmf-1+ cross would be unable to either send or receive sexual differentiation signals and thus become arrested in development.en_US
dc.description.affiliationCentre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India. kas@ccmb.res.in.en_US
dc.identifier.citationIyer SV, Ramakrishnan M, Kasbekar DP. Neurospora crassa fmf-1 encodes the homologue of the Schizosaccharomyces pombe Ste11p regulator of sexual development. Journal of Genetics. 2009 Apr; 88(1): 33-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/114423
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jgenet/index.htmlen_US
dc.subject.meshFungal Proteins --genetics
dc.subject.meshFungal Proteins --metabolism
dc.subject.meshGene Expression Regulation, Fungal
dc.subject.meshGenome, Fungal
dc.subject.meshModels, Genetic
dc.subject.meshMutation
dc.subject.meshNeurospora crassa --genetics
dc.subject.meshSchizosaccharomyces --genetics
dc.subject.meshSchizosaccharomyces pombe Proteins --genetics
dc.subject.meshTranscription Factors --genetics
dc.subject.meshTranscription Factors --metabolism
dc.titleNeurospora crassa fmf-1 encodes the homologue of the Schizosaccharomyces pombe Ste11p regulator of sexual development.en_US
dc.typeJournal Articleen_US
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