Testing a low-cost approach to giving eRIG for rabies PEP: Ethical issues

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dc.contributor.authorCash, Richard Aen_US
dc.date.accessioned2020-04-10T01:25:28Z
dc.date.available2020-04-10T01:25:28Z
dc.date.issued2019-04
dc.description.abstractEthical concerns in using a lower dose of equine rabies immune globulin (eRIG) to irrigate wounds from dog bites to prevent rabies are discussed. A lower dose of eRIG was used because of a general shortage of eRIG and the high market cost in the Himachal Pradesh state of India. The cost and availability of drugs in low- and middle-income countries (LMIC) often necessitates testing a lower dose of a vaccine or treatment than that recommended by international organizations (eg WHO). It raises the issue that recommendations may be designed for higher income countries without taking into consideration issues of supply and cost. Secondly a case-control design to compare dosages or delivery systems is usually not an option so investigators must often use historical data for comparison or other study designs. The ethical issues in the testing of drugs and vaccines in LMIC must be continuously reviewed by the international communityen_US
dc.identifier.affiliationsDepartment of Global Health and Population, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA, racash@hsph.harvard.eduen_US
dc.identifier.citationCash Richard A. Testing a low-cost approach to giving eRIG for rabies PEP: Ethical issues. Indian Journal of Medical Ethics. 2019 APR; 4(2): 144en_US
dc.identifier.issn0974-8466 
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/195196
dc.languageenen_US
dc.publisherForum for Medical Ethics Societyen_US
dc.relation.issuenumber2en_US
dc.relation.volume4en_US
dc.source.urihttps://doi.org/10.20529/IJME.2019.023en_US
dc.titleTesting a low-cost approach to giving eRIG for rabies PEP: Ethical issuesen_US
dc.typeJournal Articleen_US
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