Renin angiotensin aldosterone system and drug allergies complicated with hypotension.

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dc.contributor.authorKaraayvaz, Men_US
dc.contributor.authorCaliskaner, Zen_US
dc.contributor.authorBaykal, Yen_US
dc.contributor.authorOzanguc, Nen_US
dc.date.accessioned2009-05-27T17:21:35Z
dc.date.available2009-05-27T17:21:35Z
dc.date.issued2000-06-06en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractIt has been discussed in several studies that non-immunologic factors, such as renin angiotensin aldosterone system (RAAS) may play a role in the pathophysiology of anaphylaxis. This study aimed to determine whether RAAS plays a part in the fall in blood pressure during drug reactions or not. Twenty patients who experienced hypotension during drug reaction and 15 healthy volunteers were enrolled in this study. None of the patients in the study or control groups were under treatment with any drug that was capable of influencing to RAAS. Serum levels of angiotensin-I (A-I), angiotensin-II (A-II), angiotensin converting enzyme (ACE) and aldosterone were measured in both study and control groups. The Mann-Whitney U test was used to compare the results of the groups. There were no statistically significant differences between the groups with respect to A-I, A-II, ACE and aldosterone levels. It was concluded that a fall in blood pressure during drug reaction must be the result of mast cell mediator effects on the vascular wall rather than RAAS impairment.en_US
dc.description.affiliationDepartment of Internal Medicine, Gülhane Military Medical Academy, Ankara, Turkey.en_US
dc.identifier.citationKaraayvaz M, Caliskaner Z, Baykal Y, Ozanguc N. Renin angiotensin aldosterone system and drug allergies complicated with hypotension. Asian Pacific Journal of Allergy and Immunology. 2000 Jun; 18(2): 81-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37020
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAldosterone --blooden_US
dc.subject.meshAnaphylaxis --chemically induceden_US
dc.subject.meshAngiotensin I --blooden_US
dc.subject.meshAngiotensin II --blooden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDrug Hypersensitivity --complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypotension --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeptidyl-Dipeptidase A --blooden_US
dc.subject.meshRenin-Angiotensin System --drug effectsen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.titleRenin angiotensin aldosterone system and drug allergies complicated with hypotension.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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