Incidence of rifampicin resistance, HIV status and efficacy of fluid analysis among tuberculosis suspect pediatric cases

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dc.contributor.authorPandey, Deepmalaen_US
dc.contributor.authorYadav, Ankuren_US
dc.date.accessioned2020-09-24T07:44:33Z
dc.date.available2020-09-24T07:44:33Z
dc.date.issued2019-07
dc.description.abstractBackground: Body fluids are commonly used for diagnosis as sputum is not reliable in children. Hence it is essential to study efficacy of body fluids in comparison to GeneXpert which is a new diagnostic modality. Objectives of this study was to incidence of rifampicin resistance, HIV status and efficacy of fluid analysis among tuberculosis suspect pediatric cases.Methods: Present study was hospital based cross sectional study carried out over a period of two years at Department of Pediatrics, ACPM Medical College and Hospital from February 2016 to January 2018 among children with suspected tuberculosis. Rifampicin resistance was determined by using GeneXpert. Body fluids like CSF, pleural fluid, gastric aspirate etc were analyzed and compared with GeneXpert results.Results: Rifampicin resistance was present in 5 cases i.e. 3.3%. 15.15% Patients were HIV positive and in them 12 were GeneXpert positive with 1 Rif resistance. Different Fluid analysis showed maximum positivity with pleural fluid >TB Lymphadenitis >TBM. GeneXpert done on different body fluids showed extra case detection in different fluid analysis negative patients i.e. 28.6% extra case detection in CSF (2 cases), 87.9% in gastric aspirate (25 cases), 85.4% in induced sputum (35 cases), 14.3% in Lymph node aspirate (1 case), 50% in pleural fluid (2 case).Conclusions: : Rifampicin resistance found in present study is alarming. Among body fluids, FNAC, CSF and pleural fluids can be used reliably for diagnosis of tuberculosis where GeneXpert is not available.en_US
dc.identifier.affiliationsDepartment of Neonatology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, Indiaen_US
dc.identifier.citationPandey Deepmala, Yadav Ankur. Incidence of rifampicin resistance, HIV status and efficacy of fluid analysis among tuberculosis suspect pediatric cases. International Journal of Contemporary Pediatrics. 2019 Jul; 6(4): 1690-1694en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204164
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20192778en_US
dc.subjectBody fluidsen_US
dc.subjectDiagnosisen_US
dc.subjectFNACen_US
dc.subjectHIV statusen_US
dc.subjectResistanceen_US
dc.subjectTuberculosisen_US
dc.titleIncidence of rifampicin resistance, HIV status and efficacy of fluid analysis among tuberculosis suspect pediatric casesen_US
dc.typeJournal Articleen_US
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