Protective effect of ST-93 against ouabain induced arrhythmias in guinea pigs.

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dc.contributor.authorTripathi, R Men_US
dc.contributor.authorKaushal, Ren_US
dc.contributor.authorVeeranjaneyulu, Aen_US
dc.date.accessioned1987-04-01en_US
dc.date.accessioned2009-06-01T06:52:34Z
dc.date.available1987-04-01en_US
dc.date.available2009-06-01T06:52:34Z
dc.date.issued1987-04-01en_US
dc.description.abstractST-93, a clonidine analog was studied for its antiarrhythmic activity in anaesthetised guinea pigs against ouabain induced arrhythmia. The amount of ouabain required (micrograms/kg) for the production of ventricular premature best. Ventricular fibrillation and cardiac arrest was recorded in control and drug treated group of animals. Both ST-93 and clonidine produced significant antiarrhythmic effect in guinea pigs. This protective effect was significantly blocked by yohimbine, suggesting that the antiarrhythmic effect is mediated through presynaptic alpha 2-adrenoceptors.en_US
dc.description.affiliationDepartment of Pharmacology, IDPL Research Centre, Hyderabad.en_US
dc.identifier.citationTripathi RM, Kaushal R, Veeranjaneyulu A. Protective effect of ST-93 against ouabain induced arrhythmias in guinea pigs. Indian Journal of Physiology and Pharmacology. 1987 Apr-Jun; 31(2): 111-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107723
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Arrhythmia Agents --pharmacologyen_US
dc.subject.meshArrhythmias, Cardiac --prevention & controlen_US
dc.subject.meshClonidine --analogs & derivativesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHemodynamics --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshOuabainen_US
dc.subject.meshYohimbine --pharmacologyen_US
dc.titleProtective effect of ST-93 against ouabain induced arrhythmias in guinea pigs.en_US
dc.typeJournal Articleen_US
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