Protective effect of ST-93 against ouabain induced arrhythmias in guinea pigs.
dc.contributor.author | Tripathi, R M | en_US |
dc.contributor.author | Kaushal, R | en_US |
dc.contributor.author | Veeranjaneyulu, A | en_US |
dc.date.accessioned | 1987-04-01 | en_US |
dc.date.accessioned | 2009-06-01T06:52:34Z | |
dc.date.available | 1987-04-01 | en_US |
dc.date.available | 2009-06-01T06:52:34Z | |
dc.date.issued | 1987-04-01 | en_US |
dc.description.abstract | ST-93, a clonidine analog was studied for its antiarrhythmic activity in anaesthetised guinea pigs against ouabain induced arrhythmia. The amount of ouabain required (micrograms/kg) for the production of ventricular premature best. Ventricular fibrillation and cardiac arrest was recorded in control and drug treated group of animals. Both ST-93 and clonidine produced significant antiarrhythmic effect in guinea pigs. This protective effect was significantly blocked by yohimbine, suggesting that the antiarrhythmic effect is mediated through presynaptic alpha 2-adrenoceptors. | en_US |
dc.description.affiliation | Department of Pharmacology, IDPL Research Centre, Hyderabad. | en_US |
dc.identifier.citation | Tripathi RM, Kaushal R, Veeranjaneyulu A. Protective effect of ST-93 against ouabain induced arrhythmias in guinea pigs. Indian Journal of Physiology and Pharmacology. 1987 Apr-Jun; 31(2): 111-6 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/107723 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.ijpp.com | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anti-Arrhythmia Agents --pharmacology | en_US |
dc.subject.mesh | Arrhythmias, Cardiac --prevention & control | en_US |
dc.subject.mesh | Clonidine --analogs & derivatives | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Guinea Pigs | en_US |
dc.subject.mesh | Hemodynamics --drug effects | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Ouabain | en_US |
dc.subject.mesh | Yohimbine --pharmacology | en_US |
dc.title | Protective effect of ST-93 against ouabain induced arrhythmias in guinea pigs. | en_US |
dc.type | Journal Article | en_US |
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