Carbamazepine, Sodium Valproate and Levetiracetam Modulate Wnt Inhibitors in Indian Women with Epilepsy

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dc.contributor.authorBushra, Parveenen_US
dc.contributor.authorTripathi, Manjarien_US
dc.contributor.authorVohora, Divyaen_US
dc.date.accessioned2020-01-02T06:17:10Z
dc.date.available2020-01-02T06:17:10Z
dc.date.issued2018-07
dc.description.abstractBackground:Antiepileptic drug (AED) therapy has been claimed to deteriorate bone health. Majority of the research was inclined towards vitamin-D deficiency as the patho-mechanism. However, after the role of Wnt in bone metabolism was discovered, it has paved way for investigating the role of Wnt inhibitors in mediating effects on bone accrual. Recently, we have reported the modulation of two Wnt inhibitors, sclerostin and dickkopf-1 (DKK-1), following AED therapy in Indian women with epilepsy, however, the subgroup analysis for individual drug is elucidated in this report. Methods: Individual analysis for our earlier cross-sectional study on three AEDs, carbamazepine (CBZ), sodium valproate (SVP) and levetiracetam (LTM), on sclerostin and dickkopf-1, and their correlation with receptor activator of nuclear factor kappaB ligand (RANKL) and serum 25-hydroxy vitamin D (25OHD) was assessed in Indian women with epilepsy. Results: We observed enhanced sclerostin and 25OHD levels with all three AEDs while serum RANKL was higher with SVP and LTM only. Further, serum DKK-1 levels were lowered with CBZ and LTM. Sclerostin showed a positive correlation with RANKL in CBZ group, while DKK-1 presented no such relationshipen_US
dc.identifier.affiliationsPharmaceutical Medicine, Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhien_US
dc.identifier.affiliationsDepartment of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, New Delhien_US
dc.identifier.affiliationsDepartment of Pharmacology, School of Pharmaceutical Education and Research, In-charge, Pharmaceutical Medicine, Jamia Hamdard (Deemed to be University), New Delhi-110062. Ph: 91-11-26059688, Extn.5657. Email: divyavohora@hotmail.com, dvohra@jamiahamdard.ac.in.en_US
dc.identifier.citationBushra Parveen, Tripathi Manjari, Vohora Divya. Oxidative Stress is Independent Factor for End-stage Renal Disease in Type 2 Diabetes Mellitus Patients. Annals of the National Academy of Medical Sciences (India). 2018 Jul; 54(3): 153-159en_US
dc.identifier.issn0379-038X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189716
dc.languageenen_US
dc.publisherNational Academy of Medical Sciences (India)en_US
dc.relation.issuenumber3en_US
dc.relation.volume54en_US
dc.titleCarbamazepine, Sodium Valproate and Levetiracetam Modulate Wnt Inhibitors in Indian Women with Epilepsyen_US
dc.typeJournal Articleen_US
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