Effectiveness of ursodeoxycholic acid therapy in intrahepatic cholestatsis of pregnancy

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dc.contributor.authorPitale, Devdatt I.en_US
dc.contributor.authorJadhav, Sujata N.en_US
dc.date.accessioned2020-10-16T08:03:03Z
dc.date.available2020-10-16T08:03:03Z
dc.date.issued2020-03
dc.description.abstractBackground: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy specific disorder and commonly presents with maternal pruritus, abnormal liver function tests and adverse maternal -foetal outcomes. ICP lacks protocol-based therapy as etiology is multifactorial and is based on symptomatic treatment. The overall incidence of ICP is variable from 0.1 to 15.6% worldwide. The aim of this study is to assess the effectiveness of UDCA in ICP with regards to reduction in pruritus, normalizing LFTs and maternal-foetal outcomes.Methods: This multicentric prospective study was performed from June 2017 to December 2019 in pregnant women with ICP attending the Antenatal clinic at INHS Patanjali, MH Dehradun, INHS Asvini, INHS Sandhani. In this study, 50 women with ICP. who satisfied the inclusion and exclusion criteria were started on UDCA therapy. The effectiveness of therapy was evaluated on the basis of normalization of LFT levels, reduction in pruritus, safe confinement, maternal-foetal outcomes and adverse effects if anyResults: The pregnant women with ICP on UDCA therapy showed marked improvement in pruritus, near normal LFT levels. After the UDCA therapy the frequency and intensity of pruritus was reduced in 50 (100%) of women. Safe confinement was achieved, with normal delivery in 45 (90%) women with no any major adverse effects and adverse maternal-foetal outcomes.Conclusions: This study shows the effectiveness of URCA therapy in reducing the ICP associated pruritus, normalizing LFTs and safe confinement without any major adverse effects. UDCA therapy is an effective and safe option in ICP.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, INHS Sandhani, Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, MH Dehradun, Uttarakhand, Indiaen_US
dc.identifier.citationPitale Devdatt I., Jadhav Sujata N.. Effectiveness of ursodeoxycholic acid therapy in intrahepatic cholestatsis of pregnancy. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2020 Mar; 9(3): 1069-1072en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/207501
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-1770.ijrcog20200876en_US
dc.subjectIntrahepatic cholestasisen_US
dc.subjectPregnancyen_US
dc.subjectUrsodeoxycholic aciden_US
dc.titleEffectiveness of ursodeoxycholic acid therapy in intrahepatic cholestatsis of pregnancyen_US
dc.typeJournal Articleen_US
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